tert-Butyl rel-(3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoate

Adsorption / desorption

Administrative data

Endpoint:

adsorption / desorption: screening

Type of information:

experimental study

Adequacy of study:

key study

Study period:

05 January 2004- 05 January 2004

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2004

Report date:

2004

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))

GLP compliance:

yes

Type of method:

HPLC estimation method

Media:

soil/sewage sludge

Test material

Test material information

Constituent 1

Reference substance name:

00945

IUPAC Name:

00945

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Study design

Batch equilibrium or other method

Analytical monitoring:

yes

Results and discussion

Adsorption coefficient

Type:

log Koc

Value:

5.21

Temp.:

35 °C

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

The adsorption coefficient of the test substance was determined to be 1.6 x 105 (log Koc 5.21) at 35 degrees celsius. For four impurities, the adsorption coefficient was determined to be 6.6 x 103 (log Koc 3.82), 1.3 x 104 (log Koc 4.12), 3.7 x 104 (log Koc 4.57) and 9.1 x 104 (log Koc 4.96) at 35 degrees celsius.

Executive summary:

The adsorption coefficient of the test substance was determined to be 1.6 x 10⁵ (log Koc 5.21) at 35 degrees celsius. For four impurities, the adsorption coefficient was determined to be 6.6 x 10³ (log Koc 3.82), 1.3 x 10⁴ (log Koc 4.12), 3.7 x 10⁴ (log Koc 4.57) and 9.1 x 10⁴ (log Koc 4.96) at 35 degrees celsius.