Registration Dossier
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EC number: 807-621-3 | CAS number: 1428450-95-6
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 Dec 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
- Qualifier:
- according to guideline
- Guideline:
- other: ISO 13320 (2009)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Hess. Ministerium für Umwelt, Energie, Landwirtschaft und Verbraucherschutz, Wiesbaden, Germany
- Type of method:
- Laser scattering/diffraction
- Type of particle tested:
- primary particle
- Type of distribution:
- volumetric distribution
Test material
- Reference substance name:
- N-[4-(2,4-dihydroxyphenyl)-1,3-thiazol-2-yl]-2-methylpropanamide
- EC Number:
- 807-621-3
- Cas Number:
- 1428450-95-6
- Molecular formula:
- C13H14N2O3S
- IUPAC Name:
- N-[4-(2,4-dihydroxyphenyl)-1,3-thiazol-2-yl]-2-methylpropanamide
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
- Mass median aerodynamic diameter:
- 15 µm
Particle sizeopen allclose all
- Key result
- Percentile:
- D50
- Mean:
- ca. 12.7 µm
- St. dev.:
- 0.5
- Percentile:
- D10
- Mean:
- 2.55 µm
- Remarks on result:
- other: SD not spiecified
- Percentile:
- D90
- Mean:
- 87.6 µm
- Remarks on result:
- other: SD not specified
Any other information on results incl. tables
Two test series of 3 measurements each were performed with the fine fraction of the test item.
Test series 1:
D10: 2.59 µm
D50: 12.2 µm (Volume median diameter)
D90: 85.0 µm
Test series 2:
D10: 2.50 µm
D50: 13.1 µm (Volume median diameter)
D90: 90.1 µm
Average
D10: 2.55 µm
D50: 12.7 µm (Volume median diameter)
D90: 87.6 µm
The investigation of the test item by laser diffraction resulted in a volume median diameter (VMD) of 12.7 µm. Combined with the relative density of 1.40 and a shape factor K = 1 for spheric particles the MMAD was calculated to be 15.0 µm.
The test itemN-[4-(2,4-dihydroxyphenyl)thiazol-2-yl]isobutyramide shows a volume median diameter (VMD) D50 of 13 µm and a MMAD of 15 µm.
Applicant's summary and conclusion
- Conclusions:
- NDHPTMPA has a Volume median diameter D50 of 12.7 µm
- Executive summary:
NDHPTMPA has a Volume median diameter D50 of 12.7 µm
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