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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
10-01-2012 to 19-01-2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study performed under GLP. All relevant validity criteria were met.
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
inspected: July 2012; signature: November 2012
Type of method:
gas saturation method
Temp.:
25 °C
Vapour pressure:
0.1 Pa

Table 2: Results of the vapour pressure determinations

Saturator Column.

Temp.

[°C]

Volume, V* [mL]

Mass of Test Item in Trap 1

[μg]

Mass of Test Item in Trap 2

[μg]

Total Mass of Test Item

[μg]

Vapour Pressure

[Pa]

Average Vapour Pressure

[Pa]

A

B

C

30

39654

52872

66096

665.080

932.880

1194.880

none detected

665.080

932.880

1194.880

0.215

0.227

0.232

0.225

A

B

C

40

14789

19719

24648

879.480

1185.160

1554.560

none detected

879.480

1185.160

1554.560

0.789

0.797

0.837

0.808

A

B

C

50

6388

8518

10647

1198.920

1629.320

2116.200

 

none detected

1198.920

1629.320

2116.200

 

2.57

2.62

2.72

2.64

*Corrected volume at test temperature as calculated under “Volume correction”

Table 3: Data of the vapour pressure curve

T [°C]

1/T [K]

ln Pvp

30

3.3E-03

3.3E-03

3.3E-03

-1.54

-1.48

-1.46

40

3.19E-03

3.19E-03

3.19E-03

-0.24

-0.23

-0.18

50

3.09E-03

3.09E-03

3.09E-03

0.94

0.96

1.00

The tabulated results represent rounded-off values obtained by calculations based on the exact raw data.

Y = b x + a

where:

Y = ln (Pvp mean in Pa)

x = 1/T (K)

b = - 12062.22 (slope)

a = 38.30 (y-axis intercept)

r2= 0.9993

Validation:

The linearity of the detector response with respect to concentration was assessed over the concentration range of 20.5 to 205 mg/L. This was satisfactory with a correlation coefficient of 1.000 being obtained.

Discussion:

To ensure saturation control, three different flow rates were used at each temperature. From the data in Table 2 it can be clearly seen that higher flow rates did not lead to lower vapour pressures, which means that the nitrogen was saturated with test item under the conditions of the test.

Conclusions:
The vapour pressure of the test item has been determined to be 0.1 Pa at 25 °C.
Executive summary:

The vapour pressure was determined using EU Method A.4 and OECD TG 104 using the gas saturation method under GLP. The test item vapour pressure was calculated by extrapolation of the measured vapour pressure curve encompassing three temperatures under the conditions of the method. The calculated vapour pressure was 0.1 Pa at 25 °C.

Description of key information

Vapour Pressure: 0.1 at 25 °C, EU Method A.1 – Gas Saturation Method, 2012

Key value for chemical safety assessment

Vapour pressure:
0.1 Pa
at the temperature of:
25 °C

Additional information

The vapour pressure was determined using EU Method A.4 and OECD TG 104 using the gas saturation method under GLP. The test item vapour pressure was calculated by extrapolation of the measured vapour pressure curve encompassing three temperatures under the conditions of the method. The calculated vapour pressure was 0.1 Pa at 25 °C.

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