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Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
10th November 2015 to 26th November 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study carried out according to internationally recognised guidelines and performed according to GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2015
Report date:
2015

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chlorocyclododecanone
EC Number:
679-917-9
Cas Number:
35951-28-1
Molecular formula:
C12H21ClO
IUPAC Name:
2-chlorocyclododecanone
Constituent 2
Reference substance name:
Chlorocyclododecanone
IUPAC Name:
Chlorocyclododecanone
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
- Name of test material (as cited in study report): Chlorocyclododecanone
- CAS Number: 35951-28-1
- Physical state: white powder
- Lot/batch No.: 15-E190P
- Expiration date of the lot/batch: Sept 29, 2016

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
4.5
Temp.:
35 °C
pH:
7

Any other information on results incl. tables

The determination was performed at 35 °C (temperature of the column) but the value obtained can be considered to represent the value at an unspecified, probably ambient temperature since no mention is made in the guidelines of the temperature at which the tabulated reference substances log Pow values were determined. Partition coefficients of the test and reference substances are assumed to vary with temperature in the same way.

Applicant's summary and conclusion

Conclusions:
The log Pow of the substance, Chlorocyclododecanone, was determined using OECD guideline 117 (HPLC) to be 4.5.
Executive summary:

The Partition Coefficient n-octanol/water of Chlorocyclododecanone was determined by the Reverse Phase High Performance Liquid Chromatographic Method according to the OECD Guidelines for Testing of Chemicals, Method No. 117.

The result is:

Partition Coefficient n-octanol/water of Chlorocyclododecanone: log Pow = 4.5

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