Registration Dossier
Registration Dossier
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EC number: 226-643-9 | CAS number: 5445-19-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Methyl 2-bromohexanoate
- EC Number:
- 226-643-9
- EC Name:
- Methyl 2-bromohexanoate
- Cas Number:
- 5445-19-2
- Molecular formula:
- C7H13BrO2
- IUPAC Name:
- methyl 2-bromohexanoate
- Test material form:
- other: Liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: David Percival Ltd.
- Age at study initiation: 12 - 16 weeks
- Weight at study initiation: 2.71 - 2.84 Kg
- Housing: Suspended metal cages
- Diet (e.g. ad libitum): Free access
- Water (e.g. ad libitum): Free access
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17 - 23°C
- Humidity (%): 30 - 70%
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.1 ml
- Observation period (in vivo):
- 1, 24, 48, 72 Hours
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Score:
- > 0 - < 1
- Max. score:
- 1
- Remarks on result:
- other: Not considered to be irritant
- Irritant / corrosive response data:
- The test material produced a maximum group mean score of 9.3.
Applicant's summary and conclusion
- Interpretation of results:
- other: Minimal irritant
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The test material did not meet the criteria for classification as Irritant according to EU labelling regulations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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