Registration Dossier
Registration Dossier
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EC number: 401-990-0 | CAS number: 106990-43-6 CHIMASSORB 119; LOWILITE 19
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Body responsible for the test
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- Body responsible for the test
- IUPAC Name:
- Body responsible for the test
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: New Zealand Rabbits, KFM (SPF quality)
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 100 mg - Duration of treatment / exposure:
- 72h
- Observation period (in vivo):
- 1, 24, 48 and 72h after treatment
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: primary irritation score
- Basis:
- other: all animals
- Time point:
- other: 1 h
- Score:
- 0.3
- Irritation parameter:
- overall irritation score
- Basis:
- other: all animals
- Time point:
- other: 24h
- Score:
- 0
- Irritation parameter:
- overall irritation score
- Basis:
- other: all animals
- Time point:
- other: 48h
- Score:
- 0
- Irritation parameter:
- overall irritation score
- Basis:
- other: all animals
- Time point:
- other: 72h
- Score:
- 0
- Other effects:
- At one hour a score of one was seen in one animal. No inflammation was observed between 24 and 72 hours.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- Under the conditions of this experiment the substance was found to cause a primary irritation score of 0.3 after 1 hour. The scores were 0 in all animals at 24, 48 and 72 hours. The substance is not classified as irritating to the eye.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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