Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2015
Report date:
2015

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
GLP compliance:
yes (incl. QA statement)
Type of method:
thermal analysis

Test material

Constituent 1
Chemical structure
Reference substance name:
8-(benzoyloxy)naphthalen-1-yl benzoate
EC Number:
810-797-4
Cas Number:
331711-99-0
Molecular formula:
C24 H16 O4
IUPAC Name:
8-(benzoyloxy)naphthalen-1-yl benzoate
Constituent 2
Reference substance name:
Thane 003-6
IUPAC Name:
Thane 003-6
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
Name of test material (as cited in study report): 1,8-Naphthalenediol , 1,8-dibenzoate
Physical state: solid
Analytical purity: 99.0 g / 100 g via 1H-NMR spectroscopy
Lot/batch No.: CHPC021814NDB
Expiration date of the lot/batch: Jul29, 2014
Storage condition of test material: Room temperature, protected from moisture

Results and discussion

Melting / freezing point
Melting / freezing pt.:
179 °C
Atm. press.:
1 013.25 hPa

Any other information on results incl. tables

Results in detail

Melting temperature

Determination

Onset temperature

[°C]

Peak temperature

[°C]

A

179.5

181.6

B

179.3

181.2

Mean value

179

181

The estimated accuracy is ± 1 °C.

Observed thermic processes

After the 1 st heating the test item did not recrystallize in the same way. A sharp endothermic peak was found at 159 °C onset temperature in the 2nd heating. This might be the melting of another polymorphic form of the test item.

In order to survey the thermic behavior of the test item a preliminary TG/DTA-Test (non-GLP) was run up to 600 °C.

An endothermic peak starting at about 250 °C with a weight loss of 98 % at 400 °C showed the vaporization of the test item.

Applicant's summary and conclusion