Registration Dossier
Registration Dossier
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EC number: 930-776-4 | CAS number: -
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No apparent indication of dose group size.The background of animals and observation during treatment not indicated
Data source
Reference
- Reference Type:
- publication
- Title:
- Assessment of the male reproductive system in the preweanling rat following Mn3O4 exposure
- Author:
- Laskey JW, Rehnberg GL, Hein JF, Laws SC & Edens FW
- Year:
- 1 985
- Bibliographic source:
- Journal of Toxicology and Environmental Health, 15: 339-350
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Long-Evans rat pups were dosed orally from birth to 21 days with particulate Mn3O4 at 0, 71 or 214 mg Mn/kg body weight/day. Hypothalamic, pituitary or testicular functions were determined by measuring the endogenous or stimulated serum concentration of follicle-stimulating hormone, luteinising hormone, and/or testosterone at 21 or 28 days of age were assessed.
- GLP compliance:
- no
- Type of method:
- in vivo
Test material
- Reference substance name:
- Silicomanganese manufacturing fumes dedusting solid residues
- EC Number:
- 930-776-4
- IUPAC Name:
- Silicomanganese manufacturing fumes dedusting solid residues
- Details on test material:
- - Name of test material : Particulate Mn3O4
- Analytical purity: Not reported
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Long-Evans
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 50 % glucose solution
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- Animals were dosed once a day
- Frequency of treatment:
- Animals were dosed daily
- Duration of test:
- 21 days
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
1 µL/g body weight/day
Basis:
nominal conc.
- Remarks:
- Doses / Concentrations:
0, 71 or 214 mg Mn/kg body weight/day.
Basis:
nominal conc.
- No. of animals per sex per dose:
- Not reported
- Control animals:
- yes, concurrent vehicle
Results and discussion
Observed effects
Applicant's summary and conclusion
- Conclusions:
- There is no apparent group size indicated for the treatment, making evaluation of the results difficult for Mn3O4 exposure
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