Registration Dossier
Registration Dossier
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EC number: 406-305-9 | CAS number: 92952-81-3 PLAKATROT Z; ROT BN
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Information from migrated NONS file as per inquiry # [06-0000024522-76-0000], permission to refer granted by ECHA
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 84/449/EWG, B.4; OECD 404
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4-[(3-hydroxypropyl)amino]-3-nitrophenol
- EC Number:
- 406-305-9
- EC Name:
- 4-[(3-hydroxypropyl)amino]-3-nitrophenol
- Cas Number:
- 92952-81-3
- Molecular formula:
- C9H12N2O4
- IUPAC Name:
- 4-[(3-hydroxypropyl)amino]-3-nitrophenol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- other: Distilled water
- Controls:
- not specified
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 4 hr
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: overall at 24, 48 and 72 hr
- Score:
- 3
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: overall at 24, 48 and 72 hr
- Score:
- 2
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: overall at 24, 48 and 72 hr
- Score:
- 1.7
- Irritation parameter:
- edema score
- Max. score:
- 3
- Remarks on result:
- other: Max. duration: d; Max. value at end of observation period 0 (related to all animals)
- Irritant / corrosive response data:
- Reversibility of any observed effect : Changes fully reversible within 14 days.
- Other effects:
- Skinfold thickness : the sites of application revealed an increased skinfold thickness among all of the animals after 24 h up to 7 days p.a. 14 days p.a. only 2 out of the 3 test animals still exhibited a slightly increased skinfold thickness.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance was classified as irritating to the skin.
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