Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 221-130-6 | CAS number: 3010-02-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- prior to GLP and OECD TG, restricted reporting
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: list IV
- Author:
- Smyth H.F. et al.
- Year:
- 1 951
- Bibliographic source:
- AMA Arch. Ind. Hyg. Occup. Med. (1951) 4(2), 119-122
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Smyth H.F. et al.
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal (1962), Vol 23, pg. 95-107
Materials and methods
- Principles of method if other than guideline:
- Rats are exposed to the test substance by inhalation (vapour) and observed for 14 days.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- (diethylamino)acetonitrile
- EC Number:
- 221-130-6
- EC Name:
- (diethylamino)acetonitrile
- Cas Number:
- 3010-02-4
- Molecular formula:
- C6H12N2
- IUPAC Name:
- 2-(diethylamino)acetonitrile
- Details on test material:
- - Name of test material (as cited in study report): N,N-Diethylaminoacetonitrile
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- inhalation: vapour
- Details on inhalation exposure:
- Inhalation of metered vapor concentrations by rats is conducted with flowing streams of vapor prepared by various styles of proportioning pumps. Concentrations are in an essentially logaritmic series with a factor of two.
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- 62 and 125 ppm
- No. of animals per sex per dose:
- 6 animals per dose, sex unknown
- Details on study design:
- 14 day observation period
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 62 - 125 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: 0.29 - 0.58 mg/L
- Mortality:
- All rats survived a concentration of 62 ppm. None of the rats survived exposure to 125 ppm.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 based on GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
