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EC number: 205-080-2 | CAS number: 132-87-6
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic/sediment
BCFBAF model (v3.01) of Estimation Programs Interface (EPI Suite, 2017) prediction program was used to predict the bioconcentration factor (BCF) of test chemical 7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid (CAS No. 132 -87 -6). The bioconcentration factor (BCF) of 7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid was estimated to be 3.162 L/kg whole body w.w (at 25 deg C) which does not exceed the bioconcentration threshold of 2000, indicating that the chemical 7 -(benzoylamino)-4 -hydroxynaphthalene-2-sulfonic acid is not expected to bioaccumulate in the food chain.
Additional information
Bioaccumulation: aquatic/sediment
Various predicted data for the target compound 7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid (CAS No. 132-87-6) and the experimental study for its read across substance were reviewed for the bioaccumulation end point which are summarized as below:
In aprediction done using theBCFBAF Program(v3.01) of Estimation Programs Interface (EPI Suite, 2017), the bioconcentration factor (BCF) of test chemical 7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid (CAS No. 132 -87 -6) was estimated. The bioconcentration factor (BCF) of 7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid was estimated to be 3.162 L/kg whole body w.w (at 25 deg C).
In an another prediction done by using Bio-concentration Factor (v12.1.0.50374) module ACD (Advanced Chemistry Development)/I-Lab predictive module, 2017), the BCF over the entire pH scale (pH 0 - 14) of the test substance 7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid (CAS no. 132 -87 -6) was estimated to be 1.
Bioaccumulation test was conducted for estimating the bioconcentration factor (BCF) of test chemical 7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid (CAS no. 132 -87 -6) (ChemSpider, 2017). The estimated bioconcentration factor (BCF) of 7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid was estimated to be 1 at pH 5.5 and 7.4, respectively.
Another predicted data was estimated using SciFinder database (American Chemical Society (ACS), 2017) was used for predicting the bioconcentration factor (BCF) of test chemical 7 -(benzoylamino)-4 -hydroxy naphthalene-2 -sulfonic acid (CAS No. 132 -87 -6). The estimated bioconcentration factor (BCF) of 7 -(benzoylamino)-4 -hydroxynaphthalene-2 -sulfonic acid was estimated to be 1 (at 25 deg C).
From CompTox Chemistry Dashboard using OPERA (OPEn (quantitative) structure-activity Relationship Application) V1.02 model in which calculation based on PaDEL descriptors (calculate molecular descriptors and fingerprints of chemical), the bioaccumulation i.e BCF for test substance 7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid (CAS no. 132 -87 -6) was estimated to be 6.61 dimensionless . The predicted BCF result based on the 5 OECD principles. Thus based on the result it is concluded that the substance 7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid is non-bioaccumulative in nature.
In a supporting weight of evidence study from authoritative database (J-CHECK, 2017 and EnviChem, 2014) for the read across chemical 3-hydroxy-2-naphthanilide (CAS no. 92-77-3), bioaccumulation study was conducted on test organism Cyprinus carpio for 6 weeks for evaluating the bioconcentration factor (BCF value) of substance 3 -hydroxy-2 -naphthanilide under static conditions. The study was performed according to other guideline "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances". Cyprinus carpio was used as a test organism for the study. Details on analytical methods involve the recovery ratio: Test water: 1st concentration area : 94.9 %, 2nd concentration area : 99.5 %, Fish : 81.7 %, Limit of detection : Fish : 0.29 ppm.HCO20, Crystal sugar was used as a vehicle. Test chemical nominal conc. used for the study were0.5 mg/l and 0.05 mg/l (w/v), respectively. Range finding study involve the TLm (48 hr) of ≥ 100 ppm (100 mg/l) (w/v) on Rice fish (Oryzias latipes). Lipid content of the test organism was determined to be 3.9%.The bioconcentration factor (BCF value) of substance 3-hydroxy-2-naphthanilide on Cyprinus carpio was determined to be ≤ 0.59 – 5.9 L/Kg at a conc. of 0.5 mg/l and ≤ 6.5 L/Kg at a conc. of 0.05 mg/l, respectively.
On the basis of above results for target chemical7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid(from EPI suite, ACD labs,ChemSpider, SciFinder database and CompTox Chemistry Dashboard, 2017) and for its read across substance from J-CHECK and EnviChem, it can be concluded that the BCF value of test substance 7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid ranges from 1 – 6.61 which does not exceed the bioconcentration threshold of 2000, indicating that the chemical 7-(benzoylamino)-4-hydroxynaphthalene-2-sulfonic acid is not expected to bioaccumulate in the food chain.
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