Registration Dossier
Registration Dossier
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EC number: 229-319-5 | CAS number: 6471-78-9
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Hazard for air
Hazard for terrestrial organisms
Hazard for predators
Additional information
Aquatic toxicity
No experimental data are available regarding aquatic toxicity of 5-methoxy-2-methylsulphanilic acid. The substance should be of low concern for aquatic toxicity based of predicted values by ECOSAR v1.11 and based on read-across data with 4-aminotoluene-3-sulfonic acid .
Acute toxicity:
Predicted value by ECOSAR v.1.11 for 5-methoxy-2-methylsulphanilic are:
LC50 96h fish = 2.24*e^5 mg/l
LC50 48h Daphnid = 92436.563 mg/l
EC50 96h green algae = 18447.344 mg/l
The data reported in SIDS Dossier of 4-aminotoluene-3-sulfonic acid approved at SIAM 16 (27 -30 May 2003) regarding a compound with similar structure (4-aminotoluene-3-sulfonic acid) are:
Oryzias latipes LC50 96h > 10 mg/l
Daphnia magna EC50 48h > 10 mg/l
Selenastrum capricornutum EC 72h growth rate> 10 mg/l
Chronic toxicity:
There are no studies available for chronic toxicity to aquatic environment of 5-methoxy-2-methylsulphanilic acid. An estimated value of chronic value Daphnid for 5-methoxy-2-methylsulphanilic acid has been calculated by ECOSAR V.1.11 and it is of none concern (ChV Daphnid= 3714.701 mg/l).
The data reported in SIDS Dossier of 4-aminotoluene-3-sulfonic acid approved at SIAM 16 (27 -30 May 2003) regarding a compound with similar structure (4-aminotoluene-3-sulfonic acid) is:
NOEC Daphnia magna 21 days = 3.2 mg/l.
The predicted data for 5-methoxy-2-methylsulphanilic acid are higher and less worrying than the experimental data obtained for a similar substance (4-aminotoluene-3-sulfonic acid). In SIDS Dossier of 4-aminotoluene-3-sulfonic acid approved at SIAM 16 (27 -30 May 2003) this substance is evaluate of low concern for aquatic environmental and for analogy the same considerations should be done for 5-methoxy-2-methylsulphanilic acid.
Sediment toxicity
No data available.
Terrestrial toxicity
No data available.
Justification for read-across
See attachment document in section 13.
Conclusion on classification
According to CLP Regulation (EC n. 1272/2008), the substance should be not classified as hazardous to the aquatic environment : 5-methoxy-2-methylsulphanilic acid is not ready biodegradable but from predicted values on this substance and from read-across data with 4-aminotoluene-3-sulfonic acid there is no reason of concern.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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