Linalyl formate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: One page summary of results only with very little detail.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1962

Report date:

1962

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Miller and Tainter (Proc. Soc. Exptl. Biol. Hed. 57:261, 1944)

GLP compliance:

no

Remarks:

study pre-dates introduction of GLP

Test material

Test material information

Constituent 1

Reference substance name:

Linalyl formate

EC Number:

204-120-6

EC Name:

Linalyl formate

Cas Number:

115-99-1

Molecular formula:

C11H18O2

IUPAC Name:

linalyl formate

impurity 1

Reference substance name:

Linalyl acetate

EC Number:

204-116-4

EC Name:

Linalyl acetate

Cas Number:

115-95-7

Molecular formula:

C12H20O2

IUPAC Name:

1,5-dimethyl-1-vinylhex-4-en-1-yl acetate

impurity 2

Reference substance name:

Linalool

EC Number:

201-134-4

EC Name:

Linalool

Cas Number:

78-70-6

Molecular formula:

C10H18O

IUPAC Name:

3,7-dimethylocta-1,6-dien-3-ol

Test material form:

liquid

Specific details on test material used for the study:

Compound: Linalyl Formate

Test animals

Species:

mouse

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

not specified

Details on study design:

The compounds were administered orally to groups of 5 mice at three or more dose levels. The animals were observed for hypnosis and mortality.

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

5.9 mL/kg bw

Based on:

test mat.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

Linalyl Formate was found to have an LD50 of 5.9 mL/kg.