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EC number: 943-794-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979-10-22 to 1979-11-05
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted similarly to OECD Guideline 404 with deviations: no data about purity and no certificate of analysis of the test substance; occlusive patches were applied for 24 h and skin reactions were scored at 24 and 72 h after application; observations not followed until the reversibility of the effects
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- no data about purity and no certificate of analysis of the test substance; occlusive patches were applied for 24 h and skin reactions were scored at 24 and 72 h after application; observations not followed until the reversibility of the effects
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes
Test material
- Reference substance name:
- Tetrahydro-3-pentyl-2H-pyran-4-yl acetate
- EC Number:
- 242-640-5
- EC Name:
- Tetrahydro-3-pentyl-2H-pyran-4-yl acetate
- Cas Number:
- 18871-14-2
- Molecular formula:
- C12H22O3
- IUPAC Name:
- 3-O-acetyl-1,5-anhydro-2,4-dideoxy-2-pentylpentitol
- Reference substance name:
- Nonane-1,3-diyl diacetate
- EC Number:
- 264-060-1
- EC Name:
- Nonane-1,3-diyl diacetate
- Cas Number:
- 63270-14-4
- Molecular formula:
- C13H24O4
- IUPAC Name:
- nonane-1,3-diyl diacetate
- Reference substance name:
- 1-(tetrahydrofuran-3-yl)hexyl acetate
- Molecular formula:
- C12H22O3
- IUPAC Name:
- 1-(tetrahydrofuran-3-yl)hexyl acetate
- Reference substance name:
- 3-pentyltetrahydro-2H-pyran-4-ol
- Cas Number:
- 24646-98-8
- Molecular formula:
- C10H20O2=
- IUPAC Name:
- 3-pentyltetrahydro-2H-pyran-4-ol
- Test material form:
- liquid
- Details on test material:
- Main component of the mixture comprises of two isomers: rel-(3R,4S)-tetrahydro-3-pentyl-2H-pyran-4-yl acetate and rel-(3R,4R)-tetrahydro-3-pentyl-2H-pyran-4-yl acetate.
Constituent 1
impurity 1
impurity 2
impurity 3
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- - Source: Suitably licensed dealer
- Age at study initiation: 3 months
- Weight at study initiation: Approximately 2 kg
- Housing: Housed in galvanized or stainless steel cages.
- Diet (e.g. ad libitum): Growth and maintenance ration from a commercial producer; ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: At least 4 days
ENVIRONMENTAL CONDITIONS
- Temperature: Controlled
- Photoperiod: 12 h light / 12 h dark
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped (intact) or abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 24 h
- Observation period:
- 72 h
- Number of animals:
- Six
- Details on study design:
- - Area of exposure: Mid-dorsal area of the trunk, between the scapulae and the pelvis
- % coverage: Two test sites (2 cm2) were chosen on opposite sides of the vertebral column. The test site on the left side of the animal remained intact; the test site on the right was further prepared by abrading with a sterile 22 gauge hypodermic needle. Test substance (0.5 mL) was applied under surgical gauze (5 cm2) to the intact and abraded skin sites on each animal and the gauze was held in place with an adhesive tape.
- Type of wrap used: After both test sites were treated, the entire trunk of each animal was encased in an impermeable occlusive wrapping fixed in place with adhesive tape.
REMOVAL OF TEST SUBSTANCE
- After an exposure period of 24 h, the patches and the applied material were removed. Remaining test article was gently wiped from the skin.
SCORING SYSTEM:
- Skin reactions were scored at 24 and 72 h after application according to Draize scoring system (1975)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- other: average of 24 and 72 h
- Score:
- 0.8
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: intact skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- of 6 animals
- Time point:
- other: average of 24 and 72 h
- Score:
- 0.1
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: intact skin
- Irritant / corrosive response data:
- See table 7.3.1/1
- Other effects:
- None
Any other information on results incl. tables
Table 7.3.1/1: Skin irritation data for individual rabbits
Rabbit number |
Irritation scores (Intact skin) |
|||||
24 h |
72 h |
Mean (24 and 72 h) |
||||
Erythema |
Oedema |
Erythema |
Oedema |
Erythema |
Oedema |
|
1 |
1 |
0 |
1 |
0 |
1.0 |
0.0 |
2 |
1 |
1 |
1 |
0 |
1.0 |
0.5 |
3 |
1 |
0 |
0 |
0 |
0.5 |
0.0 |
4 |
1 |
0 |
0 |
0 |
0.5 |
0.0 |
5 |
1 |
0 |
0 |
0 |
0.5 |
0.0 |
6 |
1 |
0 |
1 |
0 |
1.0 |
0.0 |
Mean (all 6 animals) |
0.8 |
0.1 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under these test conditions, Jasmopyrane Forte is not classified as irritating to skin according to the Directive 67/548/EEC and the CLP Regulation.
- Executive summary:
In a primary dermal irritation study performed similarly to OECD Guideline 404, 0.5 mL of Jasmopyrane Forte was applied, under an occlusive patch (5 cm2), to intact and abraded skin sites on opposite sides of the vertebral column of six New Zealand White rabbits. After an exposure period of 24 h, the patches and the applied material were removed and skin reactions were scored by Draize method. A second reading was recorded 48 h later (72 h after application). Irritation scores at 48 h after application were derived using the worst case scores recorded at 24 or 72 h.
The calculated mean scores for each individual lesion for all animals within three scoring times (24 h and 72 h) were as follows: 0.8 for erythema score (intact skin) and 0.1 for oedema score (intact skin).
Under these test conditions, Jasmopyrane Forte is not classified as irritating to skin according to the Directive 67/548/EEC and the CLP Regulation.
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