Registration Dossier
Registration Dossier
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EC number: 201-983-0 | CAS number: 90-30-2
Endpoint summary
Administrative data
Description of key information
Additional information
Several studies on the bioaccumulation of N-phenyl-1-naphtylamine in fish and daphnids indicated a moderate bioaccumulation potential of the substance. It was shown that the substance accumulates in carp with BCF values ranging from 427 to 2490. Radiolabelled N-phenyl-1-naphtylamine was readily taken up in bluegill sunfish with bioconcentration factors of 600 for whole fish, 339 for edible flesh and 2063 for viscera. Half of the 14C-N-phenyl-1-naphtylamine-derived radioactivity in the fish was eliminated in about 2 days after transfer to clean flowing water, with about 50% of the radioactivity present as N-phenyl-1-naphtylamine metabolite(s). A major metabolite in the fish extract was identified as a dihydroxy derivative of PNA. For Daphnia magna, a BCF of 637 was measured, with an elimination of half of the 14C-N-phenyl-1-naphtylamine derived radioactivity within about 2 days after transfer to clean water.
QSAR calculations using the Arnot-Gobas method (including biotransformation) of BCFBAF v3.01 resulted in BCF value of 592.5 and a BAF value of 594.9 L/kg ww.
Based on these data evaluated in a weight-of evidence approach, the BCF value for whole organisms is below the bioascumualtion criterion of 2000 set in Annex XIII of REACH regulation (EC) No 1907/2006. Thus the substance is not considerd to be B or vB.
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