Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-052-3 | CAS number: 146987-98-6
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 119 ng/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 1.19 µg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 11.9 ng/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 22 mg/L
- Assessment factor:
- 1
- Extrapolation method:
- assessment factor
Hazard for air
Hazard for terrestrial organisms
Hazard for predators
Additional information
Short-term toxicity studies with freshwater fish, invertebrates and algae are available for the assessment of aquatic toxicity of Amides, C8-18, C18 unsatd, N-[3-(dimethylamino)propyl].
There are two EC50 values for the same species and end-point available thus the geometric mean was calculated for further PNEC estimation. The analysis of the test conditions was performed in order to find out why differences in response were present. The slight discrepancy in EC50 (∆ 0.067 mg/L) may result from the differences in test duration 24 h and 48 h as well as the purity of the test substance of 89.39% and 91.2%, respectively.
The most sensitive trophic level are the invertebrates (Daphnia magna) EC50 (24 h) = 0.09 mg/L (Acute toxicity test) and EC50 (48 h) = 157.2 µg/L (Acute immobilisation test).
In accordance with the Guidance on Information requirements and chemical safety assessment, R.10, an assessment factor of 1000 was applied and the PNEC aqua (freshwater) was derived from the EC50 value 118.95 µg/L, determined with Daphnia magna, the most sensitive of the organisms tested. This results in a PNECaqua (freshwater) of 119 ng/L.
An assessment factor of 10000 was applied and the PNEC aqua (marine) was derived from the EC50 value of 118.95 µg/L. This results in a PNECaqua (marine) of 11.9 ng/L.
An assessment factor of 100 was applied to the EC50 = 118.95 µg/L. Thus, the PNECaqua(Intermittent release) was calculated to be 1.19 µg/L ng/L.
Conclusion on classification
According to GHS Regulation EC No 1272/2008 Amides, C8-18, C18 unsatd, N-[3-(dimethylamino)propyl] is classified as acute aquatic hazard Category 1 with M-factor of 1 due to acute toxicity values </= 1 mg/L
Based on the 72 h EC10 in algae = 0.1 mg/L, the EC50 in Daphnia magna = 118.95 µg/L and the substance being readily biodegradable, Amides,
C8-18, C18 unsatd, N-[3-(dimethylamino)propyl] is classified as Aquatic Chronic 2.Labelling as H400 (Very toxic to aquatic life) and H411 (Toxic to aquatic life with long lasting effects) is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
