Registration Dossier
Registration Dossier
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EC number: 813-183-4 | CAS number: 881386-01-2
Guidance on Safe Use
Guidance on Safe Use
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Administrative data
First-aid measures
Eye contact : Rinse immediately with plenty of water for at least 15 minutes. Keep eye wide open while rinsing. Obtain medical attention.
Skin contact : Take off contaminated clothing and shoes immediately. Wash off immediately with plenty of water for at least 15 minutes. Obtain medical attention. Discard contaminated clothing or wash before re-use.
Inhalation : Move to fresh air. Oxygen or artificial respiration if needed. Obtain medical attention.
Ingestion : Do NOT induce vomiting. Consult a physician if necessary. Never give anything by mouth to an unconscious person.
Medical Surveillance : Employees who are pregnant, are breast-feeding, or who are concerned with other reproductive issues should be encouraged to consult with the occupational health physician monitoring worker's health.
Skin contact : Take off contaminated clothing and shoes immediately. Wash off immediately with plenty of water for at least 15 minutes. Obtain medical attention. Discard contaminated clothing or wash before re-use.
Inhalation : Move to fresh air. Oxygen or artificial respiration if needed. Obtain medical attention.
Ingestion : Do NOT induce vomiting. Consult a physician if necessary. Never give anything by mouth to an unconscious person.
Medical Surveillance : Employees who are pregnant, are breast-feeding, or who are concerned with other reproductive issues should be encouraged to consult with the occupational health physician monitoring worker's health.
Fire-fighting measures
Flammable Properties : Not available
Extinguishing Media : Suitable extinguishing media: Dry chemical, Water spray, Foam
Unsuitable extinguishing media: Do NOT use water jet.
Protection of Firefighters : Specific hazards: Not available
Protective equipment: Use personal protective equipment. In the event of fire, wear selfcontained breathing apparatus.
Hazardous Combustion Products: carbon oxides (COx), nitrogen oxides (NOx), and, gaseous hydrogen chloride (HCl).
Further Information: HCl gas can form flammable or explosive mixtures with alcohols or metals. In the event of fire and/or explosion do not breathe fumes.
Other information : Decontaminate protective clothing and equipment before reuse.
Extinguishing Media : Suitable extinguishing media: Dry chemical, Water spray, Foam
Unsuitable extinguishing media: Do NOT use water jet.
Protection of Firefighters : Specific hazards: Not available
Protective equipment: Use personal protective equipment. In the event of fire, wear selfcontained breathing apparatus.
Hazardous Combustion Products: carbon oxides (COx), nitrogen oxides (NOx), and, gaseous hydrogen chloride (HCl).
Further Information: HCl gas can form flammable or explosive mixtures with alcohols or metals. In the event of fire and/or explosion do not breathe fumes.
Other information : Decontaminate protective clothing and equipment before reuse.
Accidental release measures
Personal precautions : Use personal protective equipment.
Examples include tightly fitting safety goggles, disposable lab coat of low permeability with cuffs, double gloves and shoe covers. Wear respiratory protection. Depending on the nature of the spill (quantity and extent of spill) additional protective clothing and equipment such as a self-contained breathing apparatus may be needed.
Environmental precautions : Prevent release to drains and waterways. Prevent release to the environment.
Containment Methods : Wet down any dust to prevent generation of aerosols, if appropriate. Cover with suitable material.
Cleanup Methods : Spill prevention procedures and a spill response procedure should be implemented.
Contain and collect spillage and place in container for disposal according to local regulations. Clean spill area with a deactivating solution (if available) followed by detergent and water after spill pick-up. Handle waste materials, including gloves, protective clothing, contaminated spill cleanup material, etc., as appropriate for chemically and pharmacologically similar materials.
Examples include tightly fitting safety goggles, disposable lab coat of low permeability with cuffs, double gloves and shoe covers. Wear respiratory protection. Depending on the nature of the spill (quantity and extent of spill) additional protective clothing and equipment such as a self-contained breathing apparatus may be needed.
Environmental precautions : Prevent release to drains and waterways. Prevent release to the environment.
Containment Methods : Wet down any dust to prevent generation of aerosols, if appropriate. Cover with suitable material.
Cleanup Methods : Spill prevention procedures and a spill response procedure should be implemented.
Contain and collect spillage and place in container for disposal according to local regulations. Clean spill area with a deactivating solution (if available) followed by detergent and water after spill pick-up. Handle waste materials, including gloves, protective clothing, contaminated spill cleanup material, etc., as appropriate for chemically and pharmacologically similar materials.
Handling and storage
Handling Precautions : Highly potent material. Avoid exposure - obtain special instructions before use. Avoid formation of dust and aerosols. Keep away from heat and sources of ignition. Prevent
release to drains and waterways.
Container Requirements : Store in sturdy containers appropriate to maintain the integrity of this material for its intended use.
Storage Conditions : Store at room temperature. Keep away from heat, sparks and flames. Protect against light. Avoid moisture.
release to drains and waterways.
Container Requirements : Store in sturdy containers appropriate to maintain the integrity of this material for its intended use.
Storage Conditions : Store at room temperature. Keep away from heat, sparks and flames. Protect against light. Avoid moisture.
Transport information
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Marine transport (UN RTDG/IMDG)
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Exposure controls / personal protection
Engineering Controls and Ventilation
Use process enclosures, containment technology, or other engineering controls to keep airborne levels below recommended exposure limit. When handling quantities up to 3 milligrams, a standard laboratory with general laboratory dilution ventilation (e.g. 6-12 air changes per hour) is appropriate. When handling quantities up to 1 kilogram, work in either a standard laboratory (<500 g) or designated laboratory (500 g to <1 kg) using a fume hood, biological safety cabinet(Class II, Type A2 with thimble connection, B1, or B2)or approved vented enclosure. HEPA filtered exhaust preferred for fume hoods containing particularly "dusty" operations. Quantities exceeding 1 kilogram should be handled in a designated laboratory or containment facility using appropriate containment technology. A laminar flow/powder containment booth or appropriate isolation technology should be considered for handling more than 1 kilogram of active compound. HEPA filtered exhaust preferred. For manufacturing and pilot plant operations, barrier/containment technology and direct coupling (totally enclosed processes that create a barrier between the equipment and the room) with use of double or split butterfly valves, hybrid unidirectional airflow/local exhaust ventilation solutions (e.g. powder containment booth) should be used. Glove bags, isolator/glove box systems are optional. HEPA filtration of exhaust from dry product handling areas is required.
Respiratory protection : Use and selection of respiratory protection is based upon engineering controls in use and potential for aerosol generation. When engineering controls are not sufficient control exposure, wear an approved respirator with NIOSH Class 100 or high efficiency particulate (HEPA) filters or cartridges (EN 140/EN 136) when exposures are up to 10 times the exposure control guideline. Wear a loose-fitting (Tyvek or helmet type) HEPA powered-air purifying respirator (PAPR) (EN 12941) when exposures are 10-25 times the exposure control guideline. Wear a full facepiece negative pressure respirator with Class 100 or HEPA filters (EN 136) when exposures are 25-50 times the exposure control guideline. Wear a tightfitting, full facepiece HEPA PAPR (EN 12942) when exposures are 50-100 times the exposure control guideline. Wear a hood-shroud HEPA PAPR (EN 12941) or full facepiece supplied air respirator (EN 139) operated in a pressure demand or other positive pressure mode when exposures are 100-1000 times the exposure control guideline.
Eye protection : Safety glasses with side-shields are recommended (EN 166). Face shields or chemical safety goggles (EN 166) may be required if splash potential exists or if corrosive materials are present. Note: Choice of eye protection may be influenced by the type of respirator which is selected.
Hand protection : Wear gloves at all times when handling containers, including when unpacking, inspecting or transporting within a facility. Impervious gloves are recommended. (EN 420, EN 374). Double gloving for all manufacturing personnel potentially in direct contact with the compound should be considered. If material is handled in solution, the solvent should also be considered when selecting protective clothing material.
Skin and body protection : Wear a laboratory coat (EN 340) when handling quantities up to 500 grams. For quantities up to 1 kilogram, wear disposable laboratory coat (EN 340) or coverall of low permeability (EN 1149-1) . For quantities over 1 kilogram and manufacturing operations, wear disposable coverall of low permeability (EN 1149-1) and disposable shoe covers.
Hygiene : Wash hands and face before breaks and immediately after handling the product.
Environmental exposure controls : Prevent release to drains and waterways.
Use process enclosures, containment technology, or other engineering controls to keep airborne levels below recommended exposure limit. When handling quantities up to 3 milligrams, a standard laboratory with general laboratory dilution ventilation (e.g. 6-12 air changes per hour) is appropriate. When handling quantities up to 1 kilogram, work in either a standard laboratory (<500 g) or designated laboratory (500 g to <1 kg) using a fume hood, biological safety cabinet(Class II, Type A2 with thimble connection, B1, or B2)or approved vented enclosure. HEPA filtered exhaust preferred for fume hoods containing particularly "dusty" operations. Quantities exceeding 1 kilogram should be handled in a designated laboratory or containment facility using appropriate containment technology. A laminar flow/powder containment booth or appropriate isolation technology should be considered for handling more than 1 kilogram of active compound. HEPA filtered exhaust preferred. For manufacturing and pilot plant operations, barrier/containment technology and direct coupling (totally enclosed processes that create a barrier between the equipment and the room) with use of double or split butterfly valves, hybrid unidirectional airflow/local exhaust ventilation solutions (e.g. powder containment booth) should be used. Glove bags, isolator/glove box systems are optional. HEPA filtration of exhaust from dry product handling areas is required.
Respiratory protection : Use and selection of respiratory protection is based upon engineering controls in use and potential for aerosol generation. When engineering controls are not sufficient control exposure, wear an approved respirator with NIOSH Class 100 or high efficiency particulate (HEPA) filters or cartridges (EN 140/EN 136) when exposures are up to 10 times the exposure control guideline. Wear a loose-fitting (Tyvek or helmet type) HEPA powered-air purifying respirator (PAPR) (EN 12941) when exposures are 10-25 times the exposure control guideline. Wear a full facepiece negative pressure respirator with Class 100 or HEPA filters (EN 136) when exposures are 25-50 times the exposure control guideline. Wear a tightfitting, full facepiece HEPA PAPR (EN 12942) when exposures are 50-100 times the exposure control guideline. Wear a hood-shroud HEPA PAPR (EN 12941) or full facepiece supplied air respirator (EN 139) operated in a pressure demand or other positive pressure mode when exposures are 100-1000 times the exposure control guideline.
Eye protection : Safety glasses with side-shields are recommended (EN 166). Face shields or chemical safety goggles (EN 166) may be required if splash potential exists or if corrosive materials are present. Note: Choice of eye protection may be influenced by the type of respirator which is selected.
Hand protection : Wear gloves at all times when handling containers, including when unpacking, inspecting or transporting within a facility. Impervious gloves are recommended. (EN 420, EN 374). Double gloving for all manufacturing personnel potentially in direct contact with the compound should be considered. If material is handled in solution, the solvent should also be considered when selecting protective clothing material.
Skin and body protection : Wear a laboratory coat (EN 340) when handling quantities up to 500 grams. For quantities up to 1 kilogram, wear disposable laboratory coat (EN 340) or coverall of low permeability (EN 1149-1) . For quantities over 1 kilogram and manufacturing operations, wear disposable coverall of low permeability (EN 1149-1) and disposable shoe covers.
Hygiene : Wash hands and face before breaks and immediately after handling the product.
Environmental exposure controls : Prevent release to drains and waterways.
Stability and reactivity
Stability
Chemical Stability : Stable under normal conditions.
Conditions to avoid : Not available
Materials to avoid : Not available
Hazardous decomposition products : Hazardous decomposition products formed under fire conditions.: carbon oxides (COx), nitrogen oxides (NOx), and, gaseous hydrogen chloride (HCl).
Hazardous reactions : None known.
Sensitivity to static discharge/Dust exp.
Summary Statements : Although material has not been specifically tested, fine dust suspended in air in sufficient concentration and in the presence of an ignition source may pose a potential explosion hazard.
Provide appropriate bonding and grounding protection to control static charge. Powder handling equipment such as dust collectors, dryers, and mills may require additional protective measures (e.g. explosion venting, inerting, etc.).
Chemical Stability : Stable under normal conditions.
Conditions to avoid : Not available
Materials to avoid : Not available
Hazardous decomposition products : Hazardous decomposition products formed under fire conditions.: carbon oxides (COx), nitrogen oxides (NOx), and, gaseous hydrogen chloride (HCl).
Hazardous reactions : None known.
Sensitivity to static discharge/Dust exp.
Summary Statements : Although material has not been specifically tested, fine dust suspended in air in sufficient concentration and in the presence of an ignition source may pose a potential explosion hazard.
Provide appropriate bonding and grounding protection to control static charge. Powder handling equipment such as dust collectors, dryers, and mills may require additional protective measures (e.g. explosion venting, inerting, etc.).
Disposal considerations
Advice On Disposal And Packaging : Disposal should be in accordance with applicable regional, national and local laws and regulations. Local regulations may be more stringent than regional or national requirements. This information presented only applies to the material as supplied.
Other information : Disposal by incineration is recommended.
Other information : Disposal by incineration is recommended.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
