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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Comparative toxicity of triacetin and diethylene glycol acetate
Author:
Nosko, M.
Year:
1977
Bibliographic source:
Problemi na Khigienata (1977)3, 25-34

Materials and methods

Test guidelineopen allclose all
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)
Qualifier:
according to guideline
Guideline:
other: Deichmann, W. and Leblanc, T. J. 1943. Determination of the Approximate Lethal Dose with About 6 Animals. Journal of Industrial Hygiene and Toxicology, Vol. 25, pp. 415-417.
GLP compliance:
no
Test type:
up-and-down procedure

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: gavage

Results and discussion

Effect levelsopen allclose all
Dose descriptor:
LDLo
Effect level:
10.7 mL/kg bw
Based on:
test mat.
Dose descriptor:
LDLo
Effect level:
11 770 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met

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