Oxydiethylene di(acetate)

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Comparative toxicity of triacetin and diethylene glycol acetate

Author:

Nosko, M.

Year:

1977

Bibliographic source:

Problemi na Khigienata (1977)3, 25-34

Materials and methods

Test guideline

Test guideline 1

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)

Test guideline 2

Qualifier:

according to guideline

Guideline:

other: Deichmann, W. and Leblanc, T. J. 1943. Determination of the Approximate Lethal Dose with About 6 Animals. Journal of Industrial Hygiene and Toxicology, Vol. 25, pp. 415-417.

GLP compliance:

no

Test type:

up-and-down procedure

Test animals

Species:

rat

Administration / exposure

Route of administration:

oral: gavage

Results and discussion

Effect levels

Effect levels 1

Dose descriptor:

LDLo

Effect level:

10.7 mL/kg bw

Based on:

test mat.

Effect levels 2

Dose descriptor:

LDLo

Effect level:

11 770 mg/kg bw

Based on:

test mat.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met