Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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Reaction mass of Pentasodium 2-amino-1-((4-(4-(4-((2-(sulfonatooxy)ethyl)sulfonyl)phenyl)amino-6-chloro-1,3,5-triazin)aminodisulfonatophenyl)diazenyl)-8-hydroxy-naphthalenedisulfonate and Tetrasodium 2-amino-1-((4-(4-(4-(vinylsulfonyl)phenyl)amino-6-chloro-1,3,5-triazin)aminodisulfonatophenyl)diazenyl)-8-hydroxy-naphthalenedisulfonate
EC number: - | CAS number: -
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 april 2013 to 02 may 2013
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- radio-labelled thymidine: 3H-methyl thymidine
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
Study design: in vivo (non-LLNA)
Induction
- Route:
- other: epidermal topical application
Study design: in vivo (LLNA)
- Vehicle:
- other: ethanol/water (3+7 v/v)
- Concentration:
- 2.5, 5 and 10 % (w/w)
- No. of animals per dose:
- 4
- Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: 1.00 1.23 1.59 1.68
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: 215.6 265.1 342.1 363.2
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test item was not a skin sensitiser under the test conditions of this study.
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