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Ecotoxicological information

Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions
Justification for type of information:
None
Qualifier:
according to guideline
Guideline:
other: CIBA Method 11
Version / remarks:
Comparable to internationally accepted guidelines
Deviations:
not applicable
Principles of method if other than guideline:
None
GLP compliance:
no
Specific details on test material used for the study:
None
Analytical monitoring:
no
Details on sampling:
None
Vehicle:
not specified
Details on test solutions:
None
Test organisms (species):
other: rainbow trout
Details on test organisms:
None
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Post exposure observation period:
None
Hardness:
None
Test temperature:
13 °C
pH:
7.9-8.3
Dissolved oxygen:
None
Salinity:
None
Conductivity:
None
Nominal and measured concentrations:
20, 100 and 200 mg/L (nominal)
Details on test conditions:
None
Reference substance (positive control):
not specified
Duration:
48 h
Dose descriptor:
other: TLo
Effect conc.:
20 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Key result
Duration:
48 h
Dose descriptor:
other: TL50
Effect conc.:
57 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
48 h
Dose descriptor:
other: TL100
Effect conc.:
200 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
mortality (fish)
Details on results:
No mortality was observed at 20 mg/L, while 25% (2 out of 8) and 100% (8 out of 8) mortality was observed at 100 and 200 mg/L test concentrations.
Results with reference substance (positive control):
None
Reported statistics and error estimates:
None
Sublethal observations / clinical signs:

None

Validity criteria fulfilled:
no
Conclusions:
The LC50 (TL50) of FAT 20042/A was determined to be 57 mg/L.
Executive summary:

A study investigating short term toxicity of FAT 20042/A to fish was performed according to CIBA method A-11, which is comparable to OECD Guideline 203. Three groups of trouts (each containing 8 fish) was exposed to the test concentrations of 20, 100 and 200 mg/L for 48 hours. No mortality was observed at 20 mg/L, while 25% (2 out of 8) and 100% (8 out of 8) mortality was observed at 100 and 200 mg/L test concentrations. Hence, the LC50 (TL50) of FAT 20042/A was determined to be 57 mg/L.

Description of key information

The LC50 (TL50) of FAT 20042/A  was determined to be 57 mg/L.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
57 mg/L

Additional information

A study investigating short term toxicity of FAT 20042/B to fish was performed according to CIBA method A-11, which is comparable to OECD Guideline 203. Three groups of trouts (each containing 8 fish) was exposed to the test concentrations of 100, 200 and 1000 mg/L for 48 hours. No mortality was observed at 100 and 200 mg/L test concentrations, while 100% (8 out of 8) mortality was observed at 1000 mg/L test concentration. Hence, the LC50 (TL50) of FAT 20042/B was determined to be 450 mg/L.

A study investigating short term toxicity of FAT 20042/A to fish was performed according to CIBA method A-11, which is comparable to OECD Guideline 203. Three groups of trouts (each containing 8 fish) was exposed to the test concentrations of 20, 100 and 200 mg/L for 48 hours. No mortality was observed at 20 mg/L, while 25% (2 out of 8) and 100% (8 out of 8) mortality was observed at 100 and 200 mg/L test concentrations. Hence, the LC50 (TL50) of FAT 20042/A was determined to be 57 mg/L.

Considering the key study data, 48 hour LC50 of FAT 20042/A = 57 mg/l is been considered for hazard assessment to fish.