2-Propenoic acid, 2-methyl-, 2-hydroxyethyl ester, reaction products with phosphorus oxide

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From April 07, 2004 to May 07, 2004

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

GLP compliance:

yes

Type of method:

flask method

Specific details on test material used for the study:

Identification: PARAD Substance 139
Batch: 31104251
Physical state: slightly yellowish viscous liquid
Purity: n.a. (mixture)

Key result

Water solubility:

11 600 mg/L

Conc. based on:

test mat.

Loading of aqueous phase:

58.1 g/L

Incubation duration:

72 h

Temp.:

20 °C

pH:

1.1

Details on results:

Test substance was stirred with double distilled water (in triplicate) at a nominal concentration of approximately 58.1 g/L. Duplicate samples were taken from each water mixture after 24, 48 or 72 hours of stirring. Undissolved test substance was removed by three successive centrifugation steps (3500 g, 5 min., 20°C). The aqueous phases were analysed for the test substance. The temperature of the climate room was 20.0 ± 0.5°C during the performance of the test.
The 24-, 48- and 72- hour measurements are in agreement (i.e. maximum deviation < 15%). Therefore, the water solubility of the test substance was calculated as the mean value of all measurements.

The water solubility of a test substance is specified by the saturation mass concentration of the test substance in water at a given temperature and is expressed in g/L. Because the water solubility of the test substance was <100 g/l, no correction for the mass fraction of the test substance in the water mixture was made.

Conclusions:

Under the study conditions, the water solubility of the test substance was determined to be 11600 mg/L at 20.0°C (flask method).

Executive summary:

A study was conducted to determine the water solubility of the test substance, according to OECD guideline 105 and EU Method A.6. In a preliminary test, the water solubility of the test substance was determined to be ≥10 mg/L. Therefore the flask method was chosen for the determination of the water solubility.

Test substance was stirred with double distilled water (in triplicate) at a nominal concentration of approximately 58.1 g/L. Duplicate samples were taken from each water mixture after 24, 48 or 72 hours of stirring. Undissolved test substance was removed by three successive centrifugation steps (3500 g, 5 min., 20°C). The aqueous phases were analysed for the test substance. The temperature of the climate room was 20.0 ± 0.5°C during the performance of the test. The 24-, 48- and 72- hour measurements are in agreement (i.e. maximum deviation < 15%). Therefore, the water solubility of the test substance was calculated as the mean value of all measurements.

Under the study conditions, the water solubility of the test substance was determined to be 11600 mg/L at 20.0°C (Baltussen, 2004).

Description of key information

The water solubility was determined according to OECD guideline 105 and EU Method A.6 (flask method) (Baltussen, 2004).

Key value for chemical safety assessment

Water solubility:

11 600 mg/L

at the temperature of:

20 °C