Registration Dossier
Registration Dossier
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EC number: 258-751-7 | CAS number: 53767-93-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Reliability has been presented as 2 because similar to OECD Guideline protocol has been follo wed but not GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- Study pre-OECD guidance. However, the dosing and observations at this time are similar to the OECD 401 test guidance.
- Deviations:
- not applicable
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 2,6-dimethyloct-7-en-2-yl acetate
- EC Number:
- 258-751-7
- EC Name:
- 2,6-dimethyloct-7-en-2-yl acetate
- Cas Number:
- 53767-93-4
- Molecular formula:
- C12H22O2
- IUPAC Name:
- 2,6-dimethyloct-7-en-2-yl acetate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: oral
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 5000 mg/Kg Body weight
- No. of animals per sex per dose:
- 10 animals
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality occured
- Clinical signs:
- other: none
Applicant's summary and conclusion
- Interpretation of results:
- other: Not acute harmful.
- Remarks:
- According to Regulation (EC) No. 1272/2008 and its amendments.
- Conclusions:
- An LD50 of >5000 mg/kg bw was calculated in the acute oral toxicity study with rats.
- Executive summary:
In an acute oral toxicity study a group of 10 rats were orally exposed to 5000 mg/kg bw of the substance. The rats were observed for signs of toxicity and clinical signs for a period of 14 days. No mortality occured and no clinical signs were observed.
Based on the results, an LD50 of >5000 mg/kg bw was calculated in the acute oral toxicity study with rats.
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