Registration Dossier
Registration Dossier
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EC number: 205-413-1 | CAS number: 140-39-6
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Data is from peer-reviewed journal.
Data source
Reference
- Reference Type:
- publication
- Title:
- Fragrance material monograph for p-cresylacetate
- Author:
- D. L.J Opdyke
- Year:
- 1 974
- Bibliographic source:
- Food and Cosmetics Toxicology, Volume 12, Issue 3, June 1974, Page 391
Materials and methods
- Type of study / information:
- Case study
- Endpoint addressed:
- skin irritation / corrosion
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The patch test was performed on 25 human subjects to assess the irritation potential of p-tolyl acetate (CAS No: 140-39-6).
- GLP compliance:
- not specified
Test material
- Reference substance name:
- p-tolyl acetate
- EC Number:
- 205-413-1
- EC Name:
- p-tolyl acetate
- Cas Number:
- 140-39-6
- Molecular formula:
- C9H10O2
- IUPAC Name:
- 4-methylphenyl acetate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Name of test material (as cited in study report): p-cresyl acetate
Molecular formula: C9H10O2
Molecular weight: 150.176 g/mol
Substance Type: Organic
Physical State: Liquid
Method
- Ethical approval:
- not specified
- Details on study design:
- 25 human subjects used in the study.
Vehicle : Petrolatum
Amount/Concentration applied: 4% in petrolatum - Exposure assessment:
- not specified
- Details on exposure:
- EXPOSURE PERIOD: 48 hour
POSTEXPOSURE PERIOD: No data
Results and discussion
- Results:
- The p-tolyl acetate (CAS No. 140-39-6) tested at 4% in petrolatum produced no irritation after a 48-hr closed-patch test in 25 human subjects.
Applicant's summary and conclusion
- Conclusions:
- The p-tolyl acetate (CAS No. 140-39-6) tested at 4% in petrolatum produced no irritation after a 48-hr closed-patch test in 25 human subjects.
- Executive summary:
The p-tolyl acetate (CAS No. 140-39-6) tested at 4% in petrolatum produced no irritation after a 48-hr closed-patch test in 25 human subjects.
Thus, based on the human experience data it was concluded that p-tolyl acetate (CAS No. 140-39-6) was non-Irritating to the skin of human subjects under the experimental conditions tested and being classified as “Category- Not Classified” as per CLP Regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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