Registration Dossier

Administrative data

Endpoint:
bioaccumulation in aquatic species, other
Remarks:
all trophic levels
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Calculation based on BCFBAF v3.01, Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10. US EPA, United States Environmental Protection Agency, Washington, DC, USA.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2014
Report Date:
2014

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Calculation based on BCFBAF v3.01, Estimation Programs Interface Suite™ for Microsoft® Windows v 4.10. US EPA, United States Environmental Protection Agency, Washington, DC, USA.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline
Details on test material:
- Name of test material (as cited in study report): Isocarb 24
- Substance type: Product
- Lot/batch No.: ISC2403, 04058/MA
- Physical state: crystalline at ambient conditions

Study design

Test type:
other: calculation

Test conditions

Details on estimation of bioconcentration:
BASIS INFORMATION
- Measured/calculated logPow: calculated log Pow (US EPA EPI Suite, program KOAWIN v1.10)

BASIS FOR CALCULATION OF BCF
- Estimation software: US EPA EPI Suite v4.00, program BCFBAF v3.01
- Result based on calculated log Pow of: 10.82 (estimated, KOWWIN v.1.68)

Results and discussion

Bioaccumulation factoropen allclose all
Key result
Type:
BCF
Value:
3.162 L/kg
Basis:
whole body w.w.
Remarks on result:
other: regression-based method
Type:
BCF
Value:
3.702
Basis:
whole body w.w.
Remarks on result:
other: Arnot Gobas (including biotransformation rate estimates, upper trophic)

Any other information on results incl. tables

Estimated Log BCF from regression-based method = 0.5 (BCF = 3.162 L/kg wet-wt)

Estimated Log BCF from Arnot-Gobas method (upper trophic) = 0.568 (BCF = 3.702)

Estimated Log BAF from Arnot-Gobas method (upper trophic) = 3.861 (BAF = 7256)

Applicant's summary and conclusion

Validity criteria fulfilled:
not applicable
Conclusions:
Estimated BCF from regression-based method and BCF from Arnot-Gobas method values of 3.162 (log BCF = 0.5) and 3.702 (log BCF 0.568 - upper trophic) respectively indicate a low bioaccumulation potential of the test item.
Executive summary:

The BCF of the test item (log Pow = 10.82) was estimated to be 3.162 L/kg ww (log BCF 0.5) regression-based method using the program BCFBAF v3.01 (Part of US EPA EPI Suite v4.00). In addition, a BCF (upper trophic) of 3.702 (log BCF = 0.568) was calculated using the method of Arnot-Gobas.

 

The low BCF values indicate a low potential of the test item for bioaccumulation in aquatic organisms.