Registration Dossier
Registration Dossier
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EC number: 812-545-9 | CAS number: 93173-05-8
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 5,11-dihydro-11-((4-methyl-1-piperazinyl)acetyl)-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one monohydrochloride
- EC Number:
- 812-545-9
- Cas Number:
- 93173-05-8
- Molecular formula:
- C19H21N5O2 x HCl
- IUPAC Name:
- 5,11-dihydro-11-((4-methyl-1-piperazinyl)acetyl)-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one monohydrochloride
- Test material form:
- solid: bulk
1
Sampling and analysis
- Analytical monitoring:
- not specified
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM- Feeding during test : No feeding during test
Study design
- Test type:
- not specified
- Water media type:
- not specified
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 167.94 mg/L
- Test temperature:
- 18 - 22 °C
- pH:
- 7.0
- Dissolved oxygen:
- Not upper 60 %
- Details on test conditions:
- TEST SYSTEM- No. of organisms per vessel: 5 - No. of vessels per concentration (replicates): 4
- Reference substance (positive control):
- yes
- Remarks:
- dichromat
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1 000 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The EC50 of Pirenzepine monohydrochlorid is: 1000mg/l
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