Registration Dossier
Registration Dossier
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EC number: 203-687-7 | CAS number: 109-61-5
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound propyl chloroformate (CAS 109-61-5):
Significant accumulation in organisms is not to be expected.
Hydrolysis product propanol (CAS 71-23-8):
Significant accumulation in organisms is not to be expected.
Key value for chemical safety assessment
Additional information
Propyl chloroformate rapidly hydrolyses in contact with water to form propanol (CAS 71-23-8), hydrogen chloride (CAS 7647-01-0) and carbon dioxide (CAS 124-38-9). Due to this rapid hydrolysis, the assessment of the bioaccumulation potential of the parent compound is considered to be of low relevance.
Moreover, and in accordance with Regulation (EC) 1907/2006, Annex IX, Section 9.3.1, Column 2, the study does not need to be conducted if the substance has a low potential for bioaccumulation (for instance a log Kow ≤ 3). The estimated log Kow of 1.12 indicates no significant potential for bioaccumulation (EPI Suite v4.11, KOWWIN v1.68; BASF SE, 2022). The same refers to the hydrolysis product propanol (CAS 71-23-8), which has a measured log Kow of 0.2 (OXEA, 2010; see IUCLID Ch. 4.7).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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