1,1-dimethylurea

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

09.09. - 13.09.2013

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

GLP compliance:

not specified

Type of method:

flask method

Specific details on test material used for the study:

- Name of test material (as cited in study report): 1,1-dimethylurea
- Physical state: solid
- Expiration date of the lot/batch: 2015-12

Key result

Water solubility:

143.7 g/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

9.4

The result of the preliminary test

Sample weight：0.1025 g

The result of the preliminary test is shown in Table 2.

Table 2    Result of pre-testfor water solubility

No.	Volume of water added/mL	Results
1	0.1	Not dissolved completely
2	0.5	Not dissolved completely
3	1	Dissolved completely

 

The test result

The test result is shown in Table 3. The mass concentrations of the threecentrifuging solutiongroups are separately1.428E-01 g/mL, 1.446E-01 g/mL and 1.438E-01 g/mL.

Table 3    The result of Water Solubility

No.

Solution

Mass taken (g)

pH at 20^oC

Peak area

Average value of peak areas

Factor (f)

Average Value off

Mass concentration (g/mL, 20^oC)

1

STD1

0.04825

/

52.600

/

1.0912E+05

/

/

2

A

/

9.4

158.317

158.798

/

1.1124E+05

1.428E-01

3

159.278

4

STD2

0.02354

/

26.656

/

1.1335E+05

/

/

5

B

/

9.4

161.359

160.786

/

1.1123E+05

1.446E-01

6

160.213

7

STD1

0.04825

/

52.590

/

1.0910E+05

/

/

8

C

/

9.5

159.388

159.942

/

1.1119E+05

1.438E-01

9

160.495

10

STD2

0.02354

/

26.640

/

1.1328E+05

/

/

 

The relative difference of the concentrations measured in the three flasks respectively:

A-B，-1.3 %； A-C，-0.8 %； B-C，0.5 % .

Discussion and evaluation of Test results

According to OECD 105:

-      The concentrations measured in the three flasksdid not differ by more than 15% each other, the test was satisfactory and the average value of all results could be calculated as the water solubility.

-      The last result of water solubility was the mean of the concentrations measured in the three flasks: [(1.428+1.446+1.438)×10^-1/3] g/mL =/L, and pH = 9.4。

Conclusions:

In a study according to OECD 105 the water solubility of 1,1-Dimethylurea was determined to be 143.1 g/L (20 °C, pH 9.4).

Executive summary:

In a study according to OECD 105 the water solubility of 1,1-Dimethylurea was determined to be 143.1 g/L (20 °C, pH 9.4).

Description of key information

In a study according to OECD 105 the water solubility of 1,1-Dimethylurea was determined to be 143.1 g/L (20 °C, pH 9.4).

Key value for chemical safety assessment

Water solubility:

143.7 g/L

at the temperature of:

20 °C