Registration Dossier
Registration Dossier
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EC number: 210-789-5 | CAS number: 623-36-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
2-Methylpent-2-enal was assessed for its skin sensitising potential using the Local Lymph Node Assay (LLNA) in mice (BASF SE, 58V0505/11X140). In this study Stimulation Indices (S.I.) of 12.96, 12.89, and 16.37 were determined with the test item at concentrations of 25 and 50% (w/w), and 100% (undiluted test item) in acetone:olive oil (4+1 v/v), respectively. An EC3 value could not be calculated as all S.I.s exceeded the threshold value of 3. The mean DPM value was increased in the high dose group in comparison to the mid and low dose group. A statistically significant and biologically relevant increase in DPM values as well as in lymph node weight and lymph node cell count was observed in all test item treated groups in comparison to the vehicle control group (p<0.05). The cutoff-value for the lymph node cell count index of 1.55 for a positive response was exceeded in all dose groups. The test item 2-Methylpent-2-enal was thus found to be a skin sensitiser under the test conditions of this study.
Migrated from Short description of key information:
2-Methylpent-2-enal was found to be a skin sensitiser in the LLNA.
Justification for classification or non-classification
According to the criteria of EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 the substance has to be classified with R43/Cat. 1B (H317).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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