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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
02 to 03 August 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
4.69
Temp.:
25 °C
pH:
7.3

Results

 

The log Pow value of the test item was found to be 4.69. The data are given in the following table.

 

Results of Log Pow-Values of the test item

Test Item

Retention Time [min]

Log k’

Log Pow

Mean

Overall Mean

Solution 1

1strun

6.06

0.575

4.69

4.69

4.69

2ndrun

6.04

0.576

4.70

Solution 2

1strun

6.05

0.571

4.68

4.68

Conclusions:
A log Pow of 4.69 at 25°C was determined for the test substance according to OECD 117.

Description of key information

Log Pow: 4.69 at 25°C (OECD 117, HPLC Method)

Key value for chemical safety assessment

Log Kow (Log Pow):
4.69
at the temperature of:
25 °C

Additional information