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EC number: 945-133-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Fatty acids C16-18, C18 unsat reaction products with tetraethylenepentamine was found to be sensitising to skin in a GPMT test. These results are valid also for tall oil + TEPA, as Fatty acids C16-18, C18 unsat and Tall oil are only marginally differing in chain lengths distributions, and it is considered that both their reaction products with TEPA are principally the same when evaluating for sensitisation.
The following information is available on sensitising properties of AAI substances:
TO + DETA
Sensitising: 40% positive reaction in GPMT, i.d. induction 0.1%
TO + DETA
Sensitising: LLNA: EC3: 0.3%.
C16-18, C18 unsat + TEPA
Sensitising: 100% positive reaction in GPMT, i.d. induction 0.1%
TO + Poly(Amide)
Sensitising: 100% positive reaction in GPMT, i.d. induction 0.2%
Based on the available data, all substances in the AAI group should be considered sensitising to skin.
Classification according to CLP (ATP 2) skin sensitiser: Cat.1A (LLNA: EC 3 ≤ 2%; GPMT ≥ 30% positive at ≤ 0.1% i.d. induction or ≥ 60% positive at >0.1% i.d. induction)Migrated from Short description of key information:
Fatty acids C16-18, C18 unsat reaction products with tetraethylenepentamine was found to be sensitising to skin in a GPMT test.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
There is no information on respiratory sensitisation, but Fatty acids C16-18, C18 unsat reaction products with tetraethylenepentamine was sensitisng to skin.
The likelihood for exposure via inhalation and thus becoming sensitised to AAI, is very low, based on the high boiling point (> 300 °C) and very low vapour pressure (0.00017 mPa at 25°C for DETA based AAI).
Migrated from Short description of key information:
No data.
Justification for classification or non-classification
Various studies with different AAI indicate that these substances can cause dermal sensitisation. Fatty acids C16-18, C18 unsat reaction products with tetraethylenepentamine was sensitisng to skin in a GPMT and should be classified as dermal sensitiser Cat.1A for CLP (Criteria ATP 2, Commission Regulation 286/2011 of 10 March 2011).
The actual risk of sensitisation is probably low, as AAI are corrosive to skin and consequently exposure will be low due to necessary protetive measures to limit dermal exposure.
Also the likelihood for exposure via inhalation and thus becoming sensitised to AAI, is very low, based on the high boiling point (> 300 °C) and very low vapour pressure (0.00017 mPa at 25°C for DETA based AAI).
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