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EC number: 202-169-8 | CAS number: 92-59-1
Endpoint summary
Administrative data
Description of key information
Biodegradation in water
Biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test substance N-benzyl-N-ethylaniline (CAS no.92-59-1)(Advisory Board for Environmentally Relevant Existing Substances (BUA), 2000).The percentage degradation of test substance N-benzyl-N-ethylaniline was determined to be 0% by BOD parameter in 28 days. Thus, based on percentage degradation, N-benzyl-N-ethylaniline is considered to be not readily biodegradable in nature.
Biodegradation in water and sediment
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound N-benzyl-N-ethylaniline (CAS No. 92 -59 -1). If released in to the environment, 16.1% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of N-benzyl-N-ethylaniline in sediment is estimated to be 337.5 days (8100 hrs). Based on this half-life value, it indicates that N-benzyl-N-ethylaniline is persistent in sediment but sinceonly estimated values are available and as the percentage release of test chemical into the sediment is approx 5 % (i.e., reported as 5.47%), the substance is considered as not persistent.
Biodegradation in soil
The half-life period of N-benzyl-N-ethylaniline (CAS No. 92 -59 -1) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 78.4% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of N-benzyl-N-ethyl aniline in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of N-benzyl-N-ethylaniline, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
Additional information
Biodegradation in water
Various experimental study for the target compoundN-benzyl-N-ethylaniline(CAS No. 92-59-1) and supporting weight of evidence studies for its read across substance were reviewed for the biodegradation end point which are summarized as below:
In an experimental study from secondary source (Advisory Board for Environmentally Relevant Existing Substances (BUA), 2000), biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of test substance N-benzyl-N-ethylaniline (CAS no.92-59-1).The percentage degradation of test substance N-benzyl-N-ethylaniline was determined to be 0% by BOD parameter in 28 days. Thus, based on percentage degradation, N-benzyl-N-ethylaniline is considered to be not readily biodegradable in nature.
Another biodegradation study was conducted for evaluating the percentage biodegradability of test substance N-benzyl-N-ethylaniline (CAS no.92 -59 -1) (B.C.J. Zoeteman et. al; 1980). Rhine river surface water was used as a test inoculum obtained from Lobith or Gorinchem and the Rhine river surface water has a depth of approx. of 4 -5 meters. Initial test substance conc. used in the study was 0.001 mg/l, respectively. A careful sampling of Rhine water at Lobith was carried out for quantification of a wide range of chemicals in the water by means of GC-MS analyses of concentrates prepared by closed-loop gasstripping and XAD adsorption techniques. Assuming that reduction of the concentration of the chemicals takes place according to a first order overall process, the corresponding reaction constant and half-life was estimated from the observed drop in concentration during the known retention period. The percentage degradation of test substance N-benzyl-N-ethylaniline was determined to be 50% in 0.1 days (2.4 hrs). Thus, based on percentage degradation, N-benzyl-N-ethylaniline is considered to be readily biodegradable in nature.
In a supporting weight of evidence study from peer reviewed journal (H. Heukelekian and M. C. Rand, 1955) for the read across chemical N,N-diethylaniline (CAS no. 91-66-7), biodegradation experiment was conducted for 5 days for evaluating the percentage biodegradability of read across substance N, N-diethylaniline using standard dilution method at a temperature of 20°C. Sewage was used as a test inoculum. The 5 day BOD value of chemical N, N-diethylaniline was determined to be 0 g/g. Thus, based on this value, N, N-diethylaniline is considered to be not readily biodegradable in nature.
Additional biodegradation study was conducted for 5 days for evaluating the percentage biodegradability of read across substance N, N-diethylaniline (CAS no. 91-66-7) (HSDB, 2017). Sewage sludge was used as a test inoculum. The percentage degradation of substance N, N-diethylaniline was determined to be 5% by BOD parameter in 5 days. Thus, based on percentage degradation, N, N-diethylaniline is considered to be not readily biodegradable in nature.
For the same read across chemical N,N-diethylaniline (CAS no. 91-66-7) from authoritative database (J-CHECK and Envichem, 2017), biodegradation study was conducted for 14 days for evaluating the percentage biodegradability of read across substance N, N-diethylaniline. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of substance N, N-diethylaniline was determined to be 0% by BOD parameter in 14 days. Thus, based on percentage degradation, N, N-diethylaniline is considered to be not readily biodegradable in nature.
In a supporting weight of evidence study from authoritative database (J-CHECK, 2017) for the read across chemical N, N-dimethylaniline (CAS no. 121-69-7),biodegradation experiment was conducted for 14 days for evaluating the percentage biodegradability of read across substance N, N-dimethylaniline. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of substance N, N-dimethylaniline was determined to be1.9, 12.3 and 0% by BOD, TOC removal and GC parameter in 14 days. Thus, based on percentage degradation, N, N-dimethylaniline is considered to be not readily biodegradable in nature.
Although one study from peer reviewed journal ((B.C.J. Zoeteman et. al; 1980) indicate that the test chemicalN-benzyl-N-ethylanilineis readily biodegradable in nature, but based on the secondary source (2000) in which the study has been carried out according to standard procedure andon the basis of above results for its read across substance (from authoritative database HSDB, J-CHECK, Envichem and peer reviewed journals), it can be concluded that the test substanceN-benzyl-N-ethylanilinecan be expected to be not readily biodegradable in nature.
Biodegradation in water and sediment
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound N-benzyl-N-ethylaniline (CAS No. 92 -59 -1). If released in to the environment, 16.1% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of N-benzyl-N-ethylaniline in sediment is estimated to be 337.5 days (8100 hrs). Based on this half-life value, it indicates that N-benzyl-N-ethylaniline is persistent in sediment but sinceonly estimated values are available and as the percentage release of test chemical into the sediment is approx 5 % (i.e., reported as 5.47%), the substance is considered as not persistent.
Biodegradation in soil
The half-life period of N-benzyl-N-ethylaniline (CAS No. 92 -59 -1) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 78.4% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of N-benzyl-N-ethyl aniline in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of N-benzyl-N-ethylaniline, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
On the basis of available information, the test substance N-benzyl-N-ethylaniline can be considered to be not readily biodegradable in nature.
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