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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from ChemIDplus database

Data source

Reference
Reference Type:
other: Authoritative database
Title:
Acute oral LD50 value for CAS 587-98-4
Author:
U.S. National Library of Medicine, National Institutes of Health, Health & Human Services 
Year:
2017
Bibliographic source:
Chemidplus, a Toxnet database managed by U.S. National Library of Medicine, National Institutes of Health, Health & Human Services

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute oral LD50 value determination of substance sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate (Acid Yellow 36).
GLP compliance:
not specified
Test type:
other: not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium 3-(p-anilinophenylazo)benzenesulphonate
EC Number:
209-608-2
EC Name:
Sodium 3-(p-anilinophenylazo)benzenesulphonate
Cas Number:
587-98-4
Molecular formula:
C18H14N3O3S.Na
IUPAC Name:
sodium 3-(p-anilinophenylazo)benzenesulphonate
Test material form:
solid
Details on test material:
- Name of test material: Ext. D&C Yellow No. 1
- IUPAC name: sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate
- Molecular formula: C18H15N3O3SNa
- Molecular weight: 375.383 g/mol
- Substance type: organic
- Physical state: solid
- Purity: No data available
- Impurities (identity and concentrations): no data available
Specific details on test material used for the study:
- Name of test material : sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate
- Molecular formula : C18H14N3O3S.Na
- Molecular weight: 375.383 g/mol
- Smiles notation : c1(Nc2ccccc2)ccc(\N=N\c2cc(ccc2)S(=O)(=O)[O-])cc1.[Na+]
- InChl : 1S/C18H15N3O3S.Na/c22-25(23,24)18-8-4-7-17(13-18)21-20-16-11-9-15(10-12-16)19-14-5-2-1-3-6-14;/h1-13,19H,(H,22,23,24);/q;+1/p-1/b21-20+;
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
not specified
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: other details not available
Mortality:
not specified
Clinical signs:
other: not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: not classified
Conclusions:
The acute oral LD50 value of the test substance sodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate (Acid Yellow 36) is determined to be 5000 mg/kg for rats.
Executive summary:

The acute oral LD50 value of the test substancesodium 3-[(4-anilinophenyl)diazenyl]benzenesulfonate (Acid Yellow 36) is determined to be 5000 mg/kg for rats. This value indicates that the test substance in not toxic to rat and thus can be considered as Not classified under Acute toxicity via oral route as per CLP classification criteria.