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Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Fragrance raw materials monographs: AnisyL Formate
Author:
D.L.J. Opdyke
Year:
1976
Bibliographic source:
Food and Cosmetics toxicology, volume 14, supplement 1976, page 685

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Skin irritation tests of Anisyl Formate (CAS No: 122-91-8) was performed in rabbits to assess the degree of irritancy caused by the chemical.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Anisyl formate
EC Number:
204-582-9
EC Name:
Anisyl formate
Cas Number:
122-91-8
Molecular formula:
C9H10O3
IUPAC Name:
(4-methoxyphenyl)methyl formate
Test material form:
liquid
Details on test material:
- Name of test material: (4-methoxyphenyl)methyl formate
- Molecular formula: C9H10O3
- Molecular weight: 166.175 g/mol
- Smiles notation: c1(ccc(OC)cc1)COC=O
- InChl: 1S/C9H10O3/c1-11-9-4-2-8(3-5-9)6-12-7-10/h2-5,7H,6H2,1H3
- Substance type: Organic
- Physical state: Liquid
Specific details on test material used for the study:
- Name of test material: (4-methoxyphenyl)methyl formate/ Anisyl Formate
- Molecular formula: C9H10O3
- Molecular weight: 166.175 g/mol
- Smiles notation: c1(ccc(OC)cc1)COC=O
- InChl: 1S/C9H10O3/c1-11-9-4-2-8(3-5-9)6-12-7-10/h2-5,7H,6H2,1H3
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
No data available

Test system

Type of coverage:
occlusive
Preparation of test site:
other: Intact or abraded rabbit skin
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
100%
Duration of treatment / exposure:
24 hours
Observation period:
24 hours
Number of animals:
No data available
Details on study design:
No data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No signs of skin irritation were observed.

Applicant's summary and conclusion

Interpretation of results:
other: Not irritating
Conclusions:
The test chemical Anisyl Formate (CAS No: 122-91-8) was considered to be not irritating on intact or abraded skin of rabbits when applied in full strength.

Executive summary:

Skin irritation tests of Anisyl Formate (CAS No: 122-91-8) was performed in rabbits to assess the degree of irritancy caused by the chemical.

 

In this test, each rabbit received undiluted Anisyl Formate dermally on intact or abraded skin for 24 hours and later observed for skin reactions.

 

No known signs of skin irritation were observed. HencechemicalAnisyl Formate (CAS No: 122-91-8) was considered to be not irritating to the skin of rabbit.