Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 236-747-6 | CAS number: 13473-26-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data from secondary source
Data source
Reference
- Reference Type:
- other: Secondary source
- Title:
- Acute oral toxicity study of test chemical
- Author:
- NTP (National Toxicological Program)
- Year:
- 2 000
- Bibliographic source:
- NTP (National Toxicological Program) by Agency for Toxic Substances and Disease Registry, 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Evaluation of acute oral toxicity of test chemical in rats.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- yes
Test material
- Reference substance name:
- 2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one
- EC Number:
- 236-747-6
- EC Name:
- 2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one
- Cas Number:
- 13473-26-2
- Molecular formula:
- C20H4Br4Cl4O5
- IUPAC Name:
- 2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-3',6'-dihydroxy-3H-spiro[2-benzofuran-1,9'-xanthen]-3-one
- Test material form:
- solid
- Details on test material:
- - Name of test material: 2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-3',6'-dihydroxy-3H-spiro[2-benzofuran-1,9'-xanthen]-3-one
-Common Name: D & C Red no. 27
- Molecular formula: C20H4Br4Cl4O5
- Molecular weight : 785.6746 g/mol
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- other: Oral- by stomach tube
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 4600, 6800, 10200, 15400 and 23100 mg/kg (4.6, 6.8, 10.2, 15.4 and 23.1 g/kg)
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
- Details on study design:
- Details on study design
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: No data available
- Necropsy of survivors performed: No data available
- Other examinations performed: No data available - Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 4 600 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed
- Mortality:
- No mortality was observed at 4600mg/kg bw, while Rats treated with 15400 and 23100 mg/kg all died within 96 hr.
Two rats from each of these groups died after 36 hr. - Clinical signs:
- Sedation and anorexic were observed within one hr of treatment with doses of 6800 and 10200 mg/kg.
- Body weight:
- No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The LD50 value was considered to be > 4600mg/kg bw when rats were treated with test chemical orally.
- Executive summary:
In acute oral toxicity study, test chemical was administered by stomach tube to groups of 4 Sprague Dawley rats in doses of 4600, 6800, 10200, 15400 and 23100 mg/kg. The rats were then observed for 14 days. No effects were seen at the lowest dose, sedation and anorexic were observed within one hour of treatment with doses of 6800 and 10200 mg/kg. Two rats from each of these groups died, the remaining appeared normal after 36 hr. Rats treated with15400 and 23100 mg/kg all died within 96 hr. The test chemical was excreted percutaneously and in urine and feces. Hence,LD50 value was considered to be > 4600mg/kg bw when rats were treated with test chemical orally. Therefore according to CLP regulation, the test chemical cannot be classified for Acute oral toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
