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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
19 to 24 September 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
yes (incl. QA statement)
Remarks:
Staatliches Gewerbeaufsichtsamt Hildesheim
Type of method:
flask method
Key result
Water solubility:
1.06 g/L
Temp.:
20 °C
pH:
6.3

No significant signals were obtained for the control sample. The Tyndall-Effect check was always negative. A mean pH value of 6.3 was determined for the test item solution at 20 °C

 

The following table summarizes the results of the water solubility test.

 

Preincubation time

Replicate No.

Test item

[g/L]

Concentration

Mean

24 h

1

1.04

1.06

2

1.08

48 h

1

1.01

1.06

2

1.11

72 h

1

1.03

1.06

2

1.08

Mean (24 – 72 h)

 

1.06

Deviation [%] (24 - 72 h)

0.16
Conclusions:
A water solubility value of 1.06 g/L (at 20 ± 0.5 °C, pH = 6.3) was determined for the test substance according to OECD 105.

Description of key information

Water solubility: 1.06 g/L at ca. 20 °C, pH = 6.3 (OECD 105, shake flask method)

Key value for chemical safety assessment

Water solubility:
1.06 g/L

Additional information