Registration Dossier
Registration Dossier
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EC number: 203-705-3 | CAS number: 109-79-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
In a mouse local lymph node assay conducted according to OECD Test Guideline 429 (CiToxLAB, 2011) the stimulation index (SI) was greater than 3 at concentrations of 50% and above (5.38 and 14.40 at substance concentrations of 50% and 100% respectively). Therefore n-butylmercaptan was considered to be sensitising. The EC3 value (estimated test substance concentration that will give an SI of 3) was calculated to be 30%.
Migrated from Short description of key information:
The key mouse LLNA study (CiToxLAB, 2011) found the test substance to be sensitising.
Justification for selection of skin sensitisation endpoint:
Study was conducted according to an appropriate guideline and in compliance with GLP.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the available data n-butylmercaptan requires classification for skin sensitisation as Skin Sensitiser Category 1B: (H317: May cause allergic skin reaction), according to Regulation (EC) No 1272/2008, as amended.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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