Registration Dossier
Registration Dossier
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EC number: 219-268-7 | CAS number: 2399-48-6
Endpoint summary
Administrative data
Description of key information
According the Annex VII of REACH (Regulation EC No.1907/2008), the in vitro and in vivo studies for skin sensitisation do not need to be conducted if the substance is classified as skin corrosion.
At the time of the registration, no in vitro or in vivo data on skin sensitisation was available on the registered substance, so no new study has been performed.
The bibliographic search has showed that THFA could be associated with occuptational dermatitis in 5 humans in two publications (Munidasa 2012, Moffitt 2001).
The acrylates with low molecular weight are known to be skin sensitizers.
So based on the Weight of Evidence approach, a classification for skin sensitisation is proposed for THFA.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
So based on the Weight of Evidence approach (lower acrylate are known to be skin sensitizer, some occupational cases associated with THFA), a classification for skin sensitisation is proposed for THFA : Skin Sens.1B (H317).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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