Tetraoctylammonium bromide

Endpoint summary

Description of key information

Acute oral toxicity

LD50 was estimated to be 2294.15mg/kg bw, when female wistar rats were exposed with Tetraoctylammonium Bromide (14866-33-2) orally.

Acute dermal toxicity

LD50 was estimated to be 4805.16mg/kg bw.When male and female New Zealand White rabbits were exposed with Tetraoctylammonium Bromide (14866-33-2) by dermal application.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Justification for type of information:

Data is from OECD QSAR toolbox v3.4 and the QMRF report has been attached.

Qualifier:

equivalent or similar to guideline

Guideline:

other: As mentioned below

Principles of method if other than guideline:

Prediction was done using OECD QSAR toolbox v3.4, 2017

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Specific details on test material used for the study:

- Name of the test material: Tetraoctylammonium bromide
- IUPAC name: Tetraoctylammonium bromide
- Molecular formula: C32H68NBr
- Molecular weight: 546.8002 g/mol
- Smiles: CCCCCCCC[N+](CCCCCCCC)(CCCCCCCC)CCCCCCCC.[Br-]
- Inchi : 1S/C32H68N.BrH/c1-5-9-13-17-21-25-29-33(30-26-22-18-14-10-6-2,31-27-23-19-15-11-7-3)32-28-24-20-16-12-8-4;/h5-32H2,1-4H3;1H/q+1;/p-1
- Substance type: Organic
- Physical form: Solid powder (off white)

Species:

rat

Strain:

Wistar

Sex:

female

Details on test animals or test system and environmental conditions:

No data available

Route of administration:

oral: gavage

Vehicle:

other: sesame oil

Details on oral exposure:

No data available

Doses:

2294.15 mg/kg bw

No. of animals per sex per dose:

No data available

Control animals:

not specified

Details on study design:

No data available

Statistics:

No data available

Preliminary study:

No data available

Sex:

female

Dose descriptor:

LD50

Effect level:

2 294.15 mg/kg bw

Based on:

test mat.

Remarks on result:

other: 50% mortality was observed

Mortality:

No data available

Clinical signs:

other: No data available

Gross pathology:

No data available

Other findings:

No data available

The prediction was based on dataset comprised from the following descriptors: LD50
Estimation method: Takes average value from the 5 nearest neighbours
Domain  logical expression:Result: In Domain

(((((((((("a" or "b" or "c" or "d" )  and ("e" and ( not "f") )  )  and ("g" and ( not "h") )  )  and ("i" and ( not "j") )  )  and "k" )  and "l" )  and ("m" and ( not "n") )  )  and "o" )  and ("p" and ( not "q") )  )  and ("r" and "s" )  )

Domain logical expression index: "a"

Referential boundary: The target chemical should be classified as Ammonium salt by Organic Functional groups

Domain logical expression index: "b"

Referential boundary: The target chemical should be classified as Ammonium salt AND Overlapping groups by Organic Functional groups (nested)

Domain logical expression index: "c"

Referential boundary: The target chemical should be classified as Aliphatic Carbon [CH] OR Aliphatic Carbon [-CH2-] OR Aliphatic Carbon [-CH3] OR Nitrogen, single bonds  [N{v+5}] by Organic functional groups (US EPA) ONLY

Domain logical expression index: "d"

Referential boundary: The target chemical should be classified as Anion AND Cation AND Quaternary ammonium salt by Organic functional groups, Norbert Haider (checkmol)

Domain logical expression index: "e"

Referential boundary: The target chemical should be classified as No alert found by DNA binding by OASIS v.1.4

Domain logical expression index: "f"

Referential boundary: The target chemical should be classified as AN2 OR AN2 >> Michael-type conjugate addition to activated alkene derivatives OR AN2 >> Michael-type conjugate addition to activated alkene derivatives >> Alpha-Beta Conjugated Alkene Derivatives with Geminal Electron-Withdrawing Groups OR Non-covalent interaction OR Non-covalent interaction >> DNA intercalation OR Non-covalent interaction >> DNA intercalation >> DNA Intercalators with Carboxamide and Aminoalkylamine Side Chain OR Radical OR Radical >> Radical mechanism via ROS formation (indirect) OR Radical >> Radical mechanism via ROS formation (indirect) >> Thiols OR Radical >> ROS formation after GSH depletion (indirect) OR Radical >> ROS formation after GSH depletion (indirect) >> Haloalcohols OR SN2 OR SN2 >> Alkylation OR SN2 >> Alkylation >> Alkylphosphates, Alkylthiophosphates and Alkylphosphonates OR SN2 >> Alkylation by epoxide metabolically formed after E2 reaction OR SN2 >> Alkylation by epoxide metabolically formed after E2 reaction >> Haloalcohols OR SN2 >> Alkylation, direct acting epoxides and related OR SN2 >> Alkylation, direct acting epoxides and related >> Epoxides and Aziridines by DNA binding by OASIS v.1.4

Domain logical expression index: "g"

Referential boundary: The target chemical should be classified as No alert found by DNA binding by OECD

Domain logical expression index: "h"

Referential boundary: The target chemical should be classified as Michael addition OR Michael addition >> P450 Mediated Activation to Quinones and Quinone-type Chemicals OR Michael addition >> P450 Mediated Activation to Quinones and Quinone-type Chemicals >> Arenes OR Michael addition >> Polarised Alkenes-Michael addition OR Michael addition >> Polarised Alkenes-Michael addition >> Alpha, beta- unsaturated amides OR Michael addition >> Polarised Alkenes-Michael addition >> Alpha, beta- unsaturated esters OR Schiff base formers OR Schiff base formers >> Chemicals Activated by P450 to Glyoxal  OR Schiff base formers >> Chemicals Activated by P450 to Glyoxal  >> Ethylenediamines (including piperazine) OR SN1 OR SN1 >> Iminium Ion Formation OR SN1 >> Iminium Ion Formation >> Aliphatic tertiary amines OR SN1 >> Nitrenium Ion formation OR SN1 >> Nitrenium Ion formation >> Aromatic azo OR SN1 >> Nitrenium Ion formation >> Aromatic nitro OR SN1 >> Nitrenium Ion formation >> Primary (unsaturated) heterocyclic amine OR SN1 >> Nitrenium Ion formation >> Tertiary aromatic amine OR SN1 >> Nitrenium Ion formation >> Unsaturated heterocyclic azo OR SN2 OR SN2 >> Episulfonium Ion Formation OR SN2 >> Episulfonium Ion Formation >> Mustards OR SN2 >> SN2 at an sp3 Carbon atom OR SN2 >> SN2 at an sp3 Carbon atom >> Aliphatic halides by DNA binding by OECD

Domain logical expression index: "i"

Referential boundary: The target chemical should be classified as No alert found by Protein binding by OASIS v1.4

Domain logical expression index: "j"

Referential boundary: The target chemical should be classified as Acylation OR Acylation >> Acylation involving an activated (glucuronidated) carboxamide group OR Acylation >> Acylation involving an activated (glucuronidated) carboxamide group >> Carboxylic Acid Amides OR Acylation >> Direct acylation involving a leaving group OR Acylation >> Direct acylation involving a leaving group >> Carboxylic Acid Amides OR Acylation >> Ester aminolysis OR Acylation >> Ester aminolysis >> Amides OR AN2 OR AN2 >> Michael-type addition to quinoid structures  OR AN2 >> Michael-type addition to quinoid structures  >> Carboxylic Acid Amides OR AN2 >> Nucleophilic addition to monopyridone moiety of paraquot or diquat OR AN2 >> Nucleophilic addition to monopyridone moiety of paraquot or diquat >> Bipyridilium Herbicides OR Ionic interaction OR Ionic interaction >> Electrostatic interaction of tetraalkylamonium ion with protein carboxylates OR Ionic interaction >> Electrostatic interaction of tetraalkylamonium ion with protein carboxylates >> Tetraalkylammonium ions OR Nucleophilic addition OR Nucleophilic addition >> Addition to carbon-hetero double bonds OR Nucleophilic addition >> Addition to carbon-hetero double bonds >> Ketones OR Radical reactions OR Radical reactions >> ROS generation and protein carbonylation OR Radical reactions >> ROS generation and protein carbonylation >> Bipyridilium Herbicides OR SN2 OR SN2 >> SN2 Reaction at a sp3 carbon atom OR SN2 >> SN2 Reaction at a sp3 carbon atom >> Activated alkyl esters and thioesters  by Protein binding by OASIS v1.4

Domain logical expression index: "k"

Referential boundary: The target chemical should be classified as No superfragment by Superfragments ONLY

Domain logical expression index: "l"

Referential boundary: The target chemical should be classified as High (Class III) by Toxic hazard classification by Cramer (extension) ONLY

Domain logical expression index: "m"

Referential boundary: The target chemical should be classified as (!Undefined)Group All Lipid Solubility < 0.01 g/kg AND (!Undefined)Group CN Lipid Solubility < 0.4 g/kg AND Group All Aqueous Solubility < 0.000005 g/L AND Group All Aqueous Solubility < 0.00002 g/L AND Group All log Kow > 9 AND Group All Melting Point > 200 C AND Group CN Aqueous Solubility < 0.1 g/L AND Group CN log Kow > 4.5 AND Group CN Molecular Weight > 290 g/mol by Eye irritation/corrosion Exclusion rules by BfR

Domain logical expression index: "n"

Referential boundary: The target chemical should be classified as (!Undefined)Group All Aqueous Solubility < 0.000005 g/L OR (!Undefined)Group All Aqueous Solubility < 0.00002 g/L OR (!Undefined)Group All log Kow < -3.1 OR (!Undefined)Group All log Kow > 9 OR (!Undefined)Group All Melting Point > 200 C OR Exclusion rules not met OR Group All log Kow < -3.1 OR Group All Molecular Weight > 650 g/mol OR Group C Aqueous Solubility < 0.0001 g/L OR Group C Aqueous Solubility < 0.0005 g/L OR Group C Melting Point > 55 C OR Group C Molecular Weight > 380 g/mol OR Group CNHal Aqueous Solubility < 0.004 g/L OR Group CNHal Aqueous Solubility < 0.1 g/L OR Group CNHal log Kow > 3.8 OR Group CNHal Molecular Weight > 370 g/mol OR Group CNS Aqueous Solubility < 0.006 g/l OR Group CNS log Kow < -2 OR Group CNS log Kow > 1.5 OR Group CNS log Kow > 3.6 OR Group CNS Melting Point > 200 C OR Group CNS Melting Point > 50 C OR Group CNS Molecular Weight > 620 g/mol by Eye irritation/corrosion Exclusion rules by BfR

Domain logical expression index: "o"

Referential boundary: The target chemical should be classified as Not bioavailable by Lipinski Rule Oasis ONLY

Domain logical expression index: "p"

Referential boundary: The target chemical should be classified as -CH2-  [linear] AND Methyl  [-CH3] AND Quaternary amine by Biodegradation fragments (BioWIN MITI)

Domain logical expression index: "q"

Referential boundary: The target chemical should be classified as Aliphatic ether  [C-O-C] by Biodegradation fragments (BioWIN MITI)

Domain logical expression index: "r"

Parametric boundary:The target chemical should have a value of log Kow which is >= 7.64

Domain logical expression index: "s"

Parametric boundary:The target chemical should have a value of log Kow which is <= 12.5

Interpretation of results:

other: Not classified

Conclusions:

LD50 was estimated to be 2294.15mg/kg bw, when female wistar rats were exposed with Tetraoctylammonium Bromide (14866-33-2) orally.

Executive summary:

In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute oral toxicity was estimated for Tetraoctylammonium Bromide(14866-33-2),LD50 was estimated to be 2294.15mg/kg bw, when female wistar ratswereexposed with Tetraoctylammonium Bromide(14866-33-2) orally.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

2 294.15 mg/kg bw

Quality of whole database:

Data is Klimicsh 2 and from QSAR Toolbox 3.4. (2017)

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Link to relevant study records

Reference

Endpoint:

acute toxicity: dermal

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Justification for type of information:

Data is from OECD QSAR toolbox v3.4 and the QMRF report has been attached.

Qualifier:

equivalent or similar to guideline

Guideline:

other: As mentioned below

Principles of method if other than guideline:

Prediction was done using OECD QSAR toolbox v3.4, 2017

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Specific details on test material used for the study:

- Name of the test material: Tetraoctylammonium bromide
- IUPAC name: Tetraoctylammonium bromide
- Molecular formula: C32H68NBr
- Molecular weight: 546.8002 g/mol
- Smiles: CCCCCCCC[N+](CCCCCCCC)(CCCCCCCC)CCCCCCCC.[Br-]
- Inchi : 1S/C32H68N.BrH/c1-5-9-13-17-21-25-29-33(30-26-22-18-14-10-6-2,31-27-23-19-15-11-7-3)32-28-24-20-16-12-8-4;/h5-32H2,1-4H3;1H/q+1;/p-1
- Substance type: Organic
- Physical form: Solid powder (off white)

Species:

rabbit

Strain:

New Zealand White

Sex:

male/female

Details on test animals or test system and environmental conditions:

No data available

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

No data available

Duration of exposure:

No data available

Doses:

4805.16 mg/kg bw

No. of animals per sex per dose:

No data available

Control animals:

not specified

Details on study design:

No data available

Statistics:

No data available

Preliminary study:

No data available

Sex:

male/female

Dose descriptor:

LD50

Effect level:

4 805.16 mg/kg bw

Based on:

test mat.

Remarks on result:

other: 50% mortality was observed

Mortality:

No data available

Clinical signs:

other: No data available

Gross pathology:

No data available

Other findings:

No data available

The prediction was based on dataset comprised from the following descriptors: LD50
Estimation method: Takes average value from the 5 nearest neighbours
Domain  logical expression:Result: In Domain

((((((((("a" or "b" or "c" or "d" )  and ("e" and ( not "f") )  )  and ("g" and ( not "h") )  )  and ("i" and ( not "j") )  )  and ("k" and ( not "l") )  )  and "m" )  and "n" )  and "o" )  and ("p" and "q" )  )

Domain logical expression index: "a"

Referential boundary: The target chemical should be classified as Ammonium salt by Organic Functional groups

Domain logical expression index: "b"

Referential boundary: The target chemical should be classified as Ammonium salt AND Overlapping groups by Organic Functional groups (nested)

Domain logical expression index: "c"

Referential boundary: The target chemical should be classified as Aliphatic Carbon [CH] OR Aliphatic Carbon [-CH2-] OR Aliphatic Carbon [-CH3] OR Nitrogen, single bonds  [N{v+5}] by Organic functional groups (US EPA) ONLY

Domain logical expression index: "d"

Referential boundary: The target chemical should be classified as Anion AND Cation AND Quaternary ammonium salt by Organic functional groups, Norbert Haider (checkmol)

Domain logical expression index: "e"

Referential boundary: The target chemical should be classified as No alert found by DNA binding by OASIS v.1.4

Domain logical expression index: "f"

Referential boundary: The target chemical should be classified as SN2 OR SN2 >> Alkylation, direct acting epoxides and related OR SN2 >> Alkylation, direct acting epoxides and related >> Epoxides and Aziridines by DNA binding by OASIS v.1.4

Domain logical expression index: "g"

Referential boundary: The target chemical should be classified as No alert found by DNA binding by OECD

Domain logical expression index: "h"

Referential boundary: The target chemical should be classified as Michael addition OR Michael addition >> P450 Mediated Activation to Quinones and Quinone-type Chemicals OR Michael addition >> P450 Mediated Activation to Quinones and Quinone-type Chemicals >> Arenes OR Michael addition >> Polarised Alkenes-Michael addition OR Michael addition >> Polarised Alkenes-Michael addition >> Alpha, beta- unsaturated amides by DNA binding by OECD

Domain logical expression index: "i"

Referential boundary: The target chemical should be classified as Not known precedent reproductive and developmental toxic potential by DART scheme v.1.0

Domain logical expression index: "j"

Referential boundary: The target chemical should be classified as Known precedent reproductive and developmental toxic potential OR Miscellaneous non-cyclic chemicals (20) OR Multi-halogenated alkyl ethers (23b) by DART scheme v.1.0

Domain logical expression index: "k"

Referential boundary: The target chemical should be classified as Inclusion rules not met by Skin irritation/corrosion Inclusion rules by BfR

Domain logical expression index: "l"

Referential boundary: The target chemical should be classified as Quaternary organic ammonium compounds by Skin irritation/corrosion Inclusion rules by BfR

Domain logical expression index: "m"

Referential boundary: The target chemical should be classified as Not bioavailable by Lipinski Rule Oasis ONLY

Domain logical expression index: "n"

Similarity boundary:Target: CCCCCCCCN{+}(.Br{-})(CCCCCCCC)(CCCCCCCC)CCCCCCCC
Threshold=60%,
Dice(Atom centered fragments)
Atom type; Count H attached; Hybridization

Domain logical expression index: "o"

Referential boundary: The target chemical should be classified as days - weeks by Biodeg ultimate (Biowin 3) ONLY

Domain logical expression index: "p"

Parametric boundary:The target chemical should have a value of log Kow which is >= 9.18

Domain logical expression index: "q"

Parametric boundary:The target chemical should have a value of log Kow which is <= 10.2

Interpretation of results:

other: Not classified

Conclusions:

LD50 was estimated to be 4805.16mg/kg bw.When male and female New Zealand White rabbits were exposed with Tetraoctylammonium Bromide (14866-33-2) by dermal application.

Executive summary:

In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute dermal toxicity was estimated for Tetraoctylammonium Bromide(14866-33-2). LD50 was estimated to be 4805.16mg/kg bw.When male and femaleNew Zealand Whiterabbits wereexposed with Tetraoctylammonium Bromide(14866-33-2)by dermal application.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

4 805.16 mg/kg bw

Quality of whole database:

Data is Klimicsh 2 and from QSAR Toolbox 3.4 (2017)

Additional information

Acute oral toxicity

In different studies, Tetraoctylammonium Bromide(14866-33-2),has been investigated for acute oral toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments and estimated data in rodents, i.e. most commonly in rats Tetraoctylammonium Bromide(14866-33-2) The predicted data using the OECD QSAR toolbox has also been compared with the experimental studies.

In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute oral toxicity was estimated for Tetraoctylammonium Bromide(14866-33-2),LD50 was estimated to be 2294.15mg/kg bw, when female wistar rats were exposed with Tetraoctylammonium Bromide(14866-33-2) orally.

Based on the QSAR prediction done using the Danish (Q)SAR Database, the LD50 was estimated to be 5500mg/kg bw on rat for Tetraoctylammonium Bromide(14866-33-2) having Reliability Index: 0.52(moderate prediction quality)

Based on the QSAR prediction done using the Danish (Q)SAR Database, the LD50 was estimated to be 3100mg/kg bw on mouse for Tetraoctylammonium Bromide(14866-33-2) having Reliability Index: 0.76(high prediction quality).

 In experimental study given by HSDB (TOXNET Toxicology Data Network, 2017)

on structurally similar read across substancewith 1-Octadecanaminium- N,N-dimethyl-N-{3- (trimethoxysilyl)propyl}- chloride (27668-52-6). In acute oral toxicity study, rats were treated with1-Octadecanaminium- N,N-dimethyl-N-{3- (trimethoxysilyl)propyl}- chloride in the concentration of 5000 mg/kg bw orally. No mortality observed in treated rats at 5000 mg/kg bw. Therefore,LD50 was considered to be > 5000 mg/kg bw when rats were treated with 1-Octadecanaminium- N,N-dimethyl-N-{3- (trimethoxysilyl)propyl}- chloride orally. 

 In another experimental study given by IFA GESTIS (GESTIS SUBSTANCE Database (information system in hazardous substance of the Berufsgenossenscheftn),2017) on structurally similar read across substanceDimethyldioctadecylammonium Chloride (DODMAC) (CAS No: 107-64-2).An acute oral toxicity study of Dimethyldioctadecylammonium Chloride (DODMAC) (CAS No: 107-64-2) was carried out in 10 male and 10 female rats to determine its LD50. The substance, formulated as 20% solution in water, was administered at a various dose concentration by oral route. The observation period was 12 days. The clinical signs of toxicity like Depressions of spontaneous movement, diarrhea, piloerection, abdominal distention were observed in treated rats. No mortality occurred after application of 6,900 mg/kg to 10 males, no mortality occurred after application of 8,300 mg/kg to 10 females, 14,400 mg/kg killed 7/8 males and 6/9 females, deaths were observed on days 1-7. 50% mortality was observed at dose For male: 11,300mg/kg bw and For female: 13000mg/kg bw . Thus, LD 50 value was considered to be For male: 11,300mg/kg bw and For female: 13000mg/kg bw When male and female rats were treated with Dimethyldioctadecylammonium Chloride (DODMAC) (CAS No: 107-64-2) orally.

Thus, based on the above studies and predictions on Tetraoctylammonium Bromide(14866-33-2)and its read across substances, it can be concluded that LD50 value is 2294.15mg/kg bw. Thus, comparing this value with the criteria of CLP Tetraoctylammonium Bromide(14866-33-2) can be “Not classified” for acute oral toxicity.

 

Acute dermal toxicity

In different studies,Tetraoctylammonium Bromide(14866-33-2),has been investigated for acute dermal toxicity to a greater or lesser extent. Often are the studies based on in vivo experiments and estimated data in rodents, i.e. most commonly in rabbits forTetraoctylammonium Bromide(14866-33-2),The predicted data using the OECD QSAR toolbox has also been compared with the experimental studies.

In a prediction done by SSS (2017) using the OECD QSAR toolbox with log kow as the primary descriptor, the acute dermal toxicity was estimated for Tetraoctylammonium Bromide (14866-33-2). LD50 was estimated to be 4805.16mg/kg bw. When male and female New Zealand White rabbits were exposed with Tetraoctylammonium Bromide (14866-33-2) by dermal application.

In experimental study given byHSDB (TOXNET Toxicology Data Network, 2017 )on structurally similar read across substance 1-Octadecanaminium- N,N-dimethyl-N-{3- (trimethoxysilyl)propyl}- chloride (27668 -52 -6). In acute dermal toxicity study, rabbits were treated with1-Octadecanaminium- N,N-dimethyl-N-{3- (trimethoxysilyl)propyl}- chloride (27668 -52 -6) in the concentration of 2000 mg/kg bw dermally. No mortality observed in treated rabbits at 2000 mg/kg bw. Therefore,LD50 was considered to be >2000 mg/kg bw when rabbits were treated with1-Octadecanaminium- N,N-dimethyl-N-{3- (trimethoxysilyl)propyl}- chloride dermally. 

Also these results are further supported by experimental study given by European Chemicals Bureau (ECB) (European union Risk Assessment Report - Dimethyldioctadecylammonium Chloride (DODMAC), vol.14, 2009)on structurally similar read across substance Dimethyldioctadecylammonium Chloride (DODMAC)(107-64-2) .Acute dermal toxicity study was done in 5male and 5 female rats using test material Dimethyldioctadecylammonium Chloride (DODMAC)(107-64-2).The test substance in dose concentration 2000mg/kg bw as suspension prepared in water was applied occlusively to the skin. No mortality was observed at dose 2000mg/kg bw but skin dryness was observed. No pathologic signs were detected at necropsy. HenceLD50 was considered to be >2000mg/kg body weight. When rats were treated with Dimethyldioctadecylammonium Chloride (DODMAC)(107-64-2) by dermal application.

  Thus, based on the above studies and predictions on Tetraoctylammonium Bromide (14866-33-2)and its read across substances, it can be concluded that LD50 value is 4805.16 mg/kg bw.Thus, comparing this value with the criteria of CLP Tetraoctylammonium Bromide (14866-33-2) can be “Not classified” for acute dermal toxicity.

Justification for classification or non-classification

Thus, comparing this value with the criteria of CLP Tetraoctylammonium Bromide (14866-33-2) can be “Not classified” for acute oral and dermal toxicity.