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Diss Factsheets
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EC number: 221-083-1 | CAS number: 3001-63-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- (3-chloro-2-hydroxypropyl)dimethyloctadecylammonium chloride
- EC Number:
- 221-083-1
- EC Name:
- (3-chloro-2-hydroxypropyl)dimethyloctadecylammonium chloride
- Cas Number:
- 3001-63-6
- Molecular formula:
- C23H49ClNO.Cl
- IUPAC Name:
- (3-chloro-2-hydroxypropyl)dimethyloctadecylazanium chloride
- Reference substance name:
- Propane-1,2-diol
- EC Number:
- 200-338-0
- EC Name:
- Propane-1,2-diol
- Cas Number:
- 57-55-6
- Molecular formula:
- C3H8O2
- IUPAC Name:
- propylene glycol
- Test material form:
- liquid
- Details on test material:
- Aqueous solution
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- pH 5.85, Density: 0.99 g/ml
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: White russian (albino)
- Details on test animals or tissues and environmental conditions:
- Gender: Male, Mass: 2.0 - 2.3 kg, Age: Approximately 5 - 6 months, Acclimatization time before start of test: 1 day
Habitat: Stainless steel cages Model I Asta, Animals per cage: 1, Feeding: Standardized test animal feed, Hydration: Water ad libitum, Room temperature: 22°C +/- 1°C
Relative humidity: 50 - 60%, Lighting:12 hrs artificial light / 12 hrs darkness, Room hygiene: Laboratory and cage cleaning using standard antiseptics, instrument disinfection and sterilization by autoclave and hot air sterilizer.
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 0.1 ml / animal
- Observation period (in vivo):
- 1, 24, 48 and 72 hours after the administration of the test substance and then
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- 0.1ml of the test product was placed in the conjunctival sac of an eye after the respective lower eyelid had been carefully pulled back from the eyeball. Subsequently the lids were replaced by light finger pressure for about 1 second to prevent the loss of test substance. The other eye of each animal remained untreated and served as a control. After the administration of the test substance the treated eyes were not treated with eye-wash. The eyes were examined periodically with an opthalmascope.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not reversible
- Remarks on result:
- not determinable
- Remarks:
- The observed clinical symptoms did not permit assessment according to prescribed methodology and the determination of the degree of irritancy had therefore to be dispensed with
- Irritant / corrosive response data:
- Within the first hour after the contact of the test product with the conjunctival mucosa, they were separated and dissolved. A spreading excessive inflammatory reaction was accompanied by severe painful expressions of the animals during the forcible opening of the eyelids. The treated eyes reacted with persistent ptosis. The observed clinical symptoms did not permit assessment according to prescribed methodology and the determination of the degree of irritancy had therefore to be dispensed with.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- The test substance is corrosive to eyes.
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