Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from authoritative database

Data source

Reference
Reference Type:
other: Authoritative database
Title:
GESTIS for the CAS: 89-63-4
Author:
Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA) GESTIS-database on hazardous substance
Year:
2017
Bibliographic source:
Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA) GESTIS-database on hazardous substance, 2017

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: FDA Guidelines
Principles of method if other than guideline:
To assess the dermal irritation potential of 4-Chloro-2-nitroaniline in rabbits
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4-chloro-2-nitroaniline
EC Number:
201-925-4
EC Name:
4-chloro-2-nitroaniline
Cas Number:
89-63-4
Molecular formula:
C6H5ClN2O2
IUPAC Name:
4-Chloro-2-nitroaniline
Test material form:
solid: particulate/powder
Details on test material:
Name of the test chemical: 4-Chloro-2-nitroaniline
Molecular Formula: C6H5ClN2O2
Molecular Weight: 172.57 g/mol
InChI: 1S/C6H5ClN2O2/c7-4-1-2-5(8)6(3-4)9(10)11/h1-3H,8H2
Substance Type: Organic
Physical State: Solid
Specific details on test material used for the study:
Name of the test chemical: 4-Chloro-2-nitroaniline
Molecular Formula: C6H5ClN2O2
Molecular Weight: 172.57 g/mol
InChI: 1S/C6H5ClN2O2/c7-4-1-2-5(8)6(3-4)9(10)11/h1-3H,8H2
Purity: 99.6%
Substance Type: Organic
Physical State: Solid

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
no data available

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
full strenght
Duration of treatment / exposure:
4 hours
Observation period:
24, 48 hours
Number of animals:
no data available
Details on study design:
no data available

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24/48 h
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No irritation observed

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
Even after 24,48 hours of contact, 4-Chloro-2-nitroaniline did not cause any irritation to rabbit skin.
Hence, 4-Chloro-2-nitroaniline can be considered to be not irritating to skin.
Executive summary:

The dermal irritation potential of 4-Chloro-2-nitroaniline was assessed in rabbits. The test was performed according to FDA Guidelines. 4-Chloro-2-nitroaniline was exposed to rabbits skin for 4 hours under occlusive conditions. The rabbits were observed for effects at 24 and 48 hours. Even after 24, 48 hours of contact, 4-Chloro-2-nitroaniline did not cause any irritation to rabbit skin.

Hence, 4-Chloro-2-nitroaniline can be considered to be not irritating to skin.