Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-941-1 | CAS number: 89-80-5
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic/sediments:
The bioaccumulation study was conducted for estimating the BCF (bioaccumulation factor) value of test chemical (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one (CAS no. 89-80-5). The bioaccumulation factor (BCF) value was calculated using a water solubility and a regression derived equation. The BCF (bioaccumulation factor) value of (2R,5S)-5 -methyl-2 -(propan-2 -yl)cyclohexan-1 -one was estimated to be 15 dimensionless, which does not exceed the bioconcentration threshold of 2000, indicating that the chemical (2R,5S)-5 -methyl-2 -(propan-2 -yl)cyclohexan-1 -one is considered to be non-accumulative in aquatic organisms.
Additional information
Bioaccumulation: aquatic/sediments:
Experimental study and predicted data for the target compound (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one (CAS No. 89-80-5) and varioussupporting studiesfor its structurally similar read across substance were reviewed for the bioaccumulation end point which are summarized as below:
In an experimental key study from authoritative database (HSDB and Pubchem, 2017), bioaccumulation experiment was conducted for estimating the BCF (bioaccumulation factor) value of test chemical (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one (CAS no. 89-80-5). The bioaccumulation factor (BCF) value was calculated using a water solubility and a regression derived equation. The BCF (bioaccumulation factor) value of (2R,5S)-5 -methyl-2 -(propan-2 -yl)cyclohexan-1 -one was estimated to be 15 dimensionless.
In aprediction done using theBCFBAF Program(v3.01) of Estimation Programs Interface (EPI Suite, 2017) was used to predict the bioconcentration factor (BCF) of test chemical (2R,5S)-5 -methyl-2 -(propan-2 -yl)cyclo hexan-1 -one (CAS No. 89-80-5). The bioconcentration factor (BCF) of (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one was estimated to be 47.8 L/kg whole body w.w (at 25 deg C).
Another predicted data was estimated by using Bio-concentration Factor (v12.1.0.50374) moduleACD (Advanced Chemistry Development)/I-Lab predictive module, 2017). TheBCF over the entire pH scale (pH 1 -14) of the test substance (2R,5S)-5 -methyl-2 -(propan-2 -yl)cyclohexan-1 -one (CAS no. 89 -80 -5) was estimated to be 58.2.
In a supporting study from authoritative database (HSDB, 2017) for the test chemical , bioaccumulation experiment was conducted on test organism Cyprinus carpio for 6 weeks for evaluating the bioconcentration factor (BCF value) of test substance under static conditions. Cyprinus carpio was used as a test organism for the study. Test chemical conc. ranges from 0.02 – 0.2 mg/l (nominal concentrations), respectively. The bioconcentration factor (BCF value) of substance (-)-Menthol on Cyprinus carpio was determined to be in the range of 1-15 at a conc. of 0.02-0.2 mg/l, respectively.
In next experimental study the bioaccumulation experiment was conducted on test organism Cyprinus carpio for 6 weeks for evaluating the bioconcentration factor (BCF value) of test chemical (from authoritative database J-CHECK and HSDB, 2017).The study was performed according to other guideline "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances", respectively. Cyprinus carpio was used as a test organism for the study. Test chemical nominal conc. used for the study were 0.2 mg/land 0.02 mg/l, respectively. Test chemical solution was prepared in HCO-40. Analytical method involve the recovery ratio: Test water : 1st concentration area : 89.4 %, 2nd concentration area : 90.0 %, Fish : 74.6 %, - Limit of detection : Test water : 1st concentration area : 7.8 ng/mL, 2nd concentration area : 0.78 ng/mL, Fish : 63 ng/g. Range finding study involve theLC50(48h) 26 mg/L on Rice fish (Oryzias latipes). Lipid content of the test organism Cyprinus carpio was determined to be 4.7%. The bioconcentration factor (BCF value) of test substance on Cyprinus carpio was determined to be 0.5-15 L/Kg at a conc. of 0.2 mg/l and 4.6-11 L/Kg at a conc. of 0.02 mg/l, respectively.
On the basis of above results for target chemical (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one (from authoritative database HSDB, PubChem, EPI suite and ACD labs,2017) , it can be concluded that the BCF value of test substance (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one ranges from 15 –58.2 which does not exceed the bioconcentration threshold of 2000, indicating that the chemical (2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-one is not expected to bioaccumulate in the food chain
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
