Registration Dossier
Registration Dossier
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Reaction mass of trisodium bis[5-amino-2-(hydroxy-κO)-3-{[1-(hydroxy-κO)-2-naphthyl]diazenyl-κN1}benzenesulfonato(3-)]chromate(3-), trisodium bis[2-(hydroxy-κO)-3-{[1-(hydroxy-κO)-2-naphthyl]diazenyl-κN1}-5-nitrobenzenesulfonato(3-)]chromate(3-) and heptasodium bis[4-(hydroxy-κO)-3-{[2-(hydroxy-κO)-5-nitro-3-sulfophenyl]diazenyl-κN2}-6-(4-sulfoanilino)naphthalene-2-sulfonato(5-)]chromate(7-)
EC number: 944-619-2 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- other: data obtained after Article 25(3) request
- Title:
- Unnamed
- Year:
- 2 017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Acid Black 173 - Similar Substance 01
- IUPAC Name:
- Acid Black 173 - Similar Substance 01
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Wistar Bor:WISW (SPFCpb)
- Sex:
- male/female
Administration / exposure
- Route of administration:
- other:
- Vehicle:
- water
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- No symptoms of poisoning were observed in either of the sexes. No mortalities occurred. A slight reduction in body weight was determined for one female animal in the second week. The body weight development among all of the males and the remaining female rats was not influenced.
- Gross pathology:
- None
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP criteria not met
- Conclusions:
- LD50 > 2000 mg/kg bw
- Executive summary:
Method
The substance has been tested according to the EU method B.1.
Results
LD50 > 2000 mg/kg bw
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