Registration Dossier
Registration Dossier
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EC number: 257-170-6 | CAS number: 51388-20-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 431 (In Vitro Skin Corrosion: Human Skin Model Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 4-benzyloxyaniline hydrochloride
- EC Number:
- 257-170-6
- EC Name:
- 4-benzyloxyaniline hydrochloride
- Cas Number:
- 51388-20-6
- Molecular formula:
- C13H13NO.ClH
- IUPAC Name:
- 4-benzyloxyaniline hydrochloride
- Test material form:
- solid
1
In vitro test system
- Test system:
- human skin model
- Source species:
- human
- Cell type:
- non-transformed keratinocytes
- Control samples:
- yes, concurrent negative control
- yes, concurrent positive control
- Amount/concentration applied:
- About 25 mg of the test item was spread evenly over the surface of the tissue and wetted with 25 μL deionised water.
For the positive and negative control tissues a volume of 50 μL was applied to each tissue. - Duration of treatment / exposure:
- 3 minutes and 1 hour.
- Number of replicates:
- Independent duplicate tissues were exposed to the test item, the negative control or the positive control.
Results and discussion
In vitro
Resultsopen allclose all
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- 3 minutes treatment
- Value:
- 89.7
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- 1 hour treatment
- Value:
- 68.3
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In conclusion, it can be stated that in this study and under the reported experimental conditions, the test item BOA.HCl was non corrosive to skin according to UN GHS / EU CLP Cat.1 / DSD (67/548/EEC).
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