Registration Dossier
Registration Dossier
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EC number: 201-814-0 | CAS number: 88-24-4
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The 72h-NOEC of 6,6'-di-tert-butyl-4,4'-diethyl-2,2'-methylenediphenol at the water saturation level under the conditions of this test is higher than the highest concentration tested (saturated solution at a loading rate of 100 mg test item/L).
Key value for chemical safety assessment
Additional information
A GLP compliant 72 hour static toxicity test withRaphidocelis subcapitata was performed in accordance with OECD 201 to assess the toxicity of 6,6'-di-tert-butyl-4,4'-diethyl-2,2'-methylenediphenol. Nominal test concentrations were:100, 45.5, 20.7, 9.39 and 4.27% of the filtrate of a saturated solution at a loading rate of 100 mg/L, and a control. The initially measured test item concentrations at 20.7, 45.5 and 100% of the filtrate of a saturated solution at a loading of 100 mg/L were 1, 1, and 5 µg/L, respectively. All other measured test item concentrations were below the LOD.
The EC50 of Raphidocelis subcapitatawas not determined since a concentration-response relationship was not observed. It is therefore concluded that the EC50 of the test item under the conditions of this test is higher than the highest concentration tested (saturated solution at a loading rate of 100 mg test item/L).
No concentration-response relationship was observed for the biological parameters growth rate and yield during the exposure period.It is therefore concluded that the biologically relevant NOEC is 100% of the filtrate of a saturated solution at a loading rate of 100 mg test item/L.
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