Diallylamine

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Data source

Reference

Reference Type:

publication

Title:

Diallylamine [124-02-7]: Review of Toxicological Literature

Author:

US National Toxicology Program

Year:

1997

Bibliographic source:

US National Toxicology Program

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Rats were administered, by gavage, a single dose of diallylamine.

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Diallylamine

EC Number:

204-671-2

EC Name:

Diallylamine

Cas Number:

124-02-7

Molecular formula:

C6H11N

IUPAC Name:

diallylamine

Specific details on test material used for the study:

Purity not provided.

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

Female and male rats were administered, by gavage, a sinlge dose of diallylamine.

Doses:

Females: 215, 464, 1000 and 4640 mg/k (2.21, 4.78, 10.29 and 47.76 mmol/kg)
Males: 215, 464, 1000 and 2150 (2.21, 4.78, 10.29 and 22.13 mmol/kg)

No. of animals per sex per dose:

5 females and 5 males per dose.

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Frequency of observations not stated. No details on weights available.
- Necropsy of survivors performed: Not specified.

Results and discussion

Effect levels

Effect levels 1

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

316 mg/kg bw

Based on:

test mat.

95% CL:

>= 205 - <= 488

Effect levels 2

Sex:

female

Dose descriptor:

LD50

Effect level:

501 mg/kg bw

Based on:

test mat.

95% CL:

>= 344 - <= 730

Mortality:

Females: No observable effects occurred at the lowest tested dose (215 mg/kg), while mortality was induced at higher doses within 20 hours of dosing.
Males: At lower doses, death sometimes occurred a week or later after dosing, while at 1000 mg/kg and higher, all male rats died within 2 hours.
Mortality
215 MG/KG (1/5M, 0/5F),
464 MG/KG (4/5M, 2/5F),
1000 MG/KG (5/5M, 5/5F),
2150 MG/KG (5/5M).
4640 MG/KG (5/5F).

Clinical signs:

Females: No observable effects occurred at the lowest dose (215 mg/kg).
Males: Rats exhibited a dose-dependent depression (lethargy) in all exposed groups.

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

Rat acute oral LD50 for diallylamine reported lowest value of 316 mg/k (3.25 mmol/kg) for males and 501 mg/kg (5.16 mmol/kg) for females.

Executive summary:

Female Sprague-Dawley rats were administered, by gavage, a single dose of diallylamine at 215, 464, 1000 and 4640 mg/k (2.21, 4.78, 10.29 and 47.76 mmol/kg).

No observable effects occurred at the lowest tested dose, while mortality was induced at higher doses within 20 hours of dosing.

In the same study, male Sprague-Dawley rats administered diallylamine at 215, 464, 1000 and 2150 (2.21, 4.78, 10.29 and 22.13 mmol/kg) exhibited a dose-dependent depression (lethargy) in all exposed groups. At lower doses, death sometimes occurred a week or later after dosing, while at 1000 mg/kg and higher, all male rats died within 2 hours.

Based on the results of the study the following LD50 values were reported: 316 mg/k (3.25 mmol/kg) for males and 501 mg/kg (5.16 mmol/kg) for females.