Registration Dossier
Registration Dossier
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EC number: 233-242-2 | CAS number: 10099-70-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- July 10, 2020
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- The model is been assessed according to the OECD principles for the validation of QSAR, to generate a transparent, understandable, reproducible and verifiable result.
Data source
Reference
- Reference Type:
- publication
- Title:
- QSAR Application Toolbox Workflow
- Author:
- Laboratory of Mathematical Chemistry, Bourgas University “Prof. Assen Zlatarov” Bulgaria
- Year:
- 2 015
- Bibliographic source:
- https://echa.europa.eu/documents/10162/22838464/QSAR_Toolbox_workflow_en.pdf/
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: ECHA Guidance on information requirements and chemical safety assessment - Chapter R.06: QSARs and grouping of chemicals
- Principles of method if other than guideline:
- Prediction was calculated using QSAR Toolbox v.4.4.1
Data gap filling method: Read-across analysis
Test material
- Reference substance name:
- Diisopropyl maleate
- EC Number:
- 233-242-2
- EC Name:
- Diisopropyl maleate
- Cas Number:
- 10099-70-4
- Molecular formula:
- C10H16O4
- IUPAC Name:
- dipropan-2-yl (Z)-but-2-enedioate
Constituent 1
Results and discussion
In vitro
Results
- Remarks on result:
- no indication of irritation
- Remarks:
- According to the (Q)SAR Toolbox results
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Diisopropyl maleate is not predicted to exhibit skin irritation by QSAR Toolbox, evaluating experimental existing data on similar substances.
- Executive summary:
Diisopropyl maleate is not predicted to exhibit skin irritation by QSAR Toolbox, evaluating experimental existing data on similar substances.
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