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EC number: 245-010-8 | CAS number: 22457-23-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 5-methylheptan-3-one oxime
- EC Number:
- 245-010-8
- EC Name:
- 5-methylheptan-3-one oxime
- Cas Number:
- 22457-23-4
- Molecular formula:
- C8H17NO
- IUPAC Name:
- 5-methylheptan-3-one oxime
- Reference substance name:
- (E)-3,4-dimethylhexan-2-one oxime
- IUPAC Name:
- (E)-3,4-dimethylhexan-2-one oxime
- Reference substance name:
- (Z)-3,4-dimethylhexan-2-one oxime
- IUPAC Name:
- (Z)-3,4-dimethylhexan-2-one oxime
- Test material form:
- liquid
Constituent 1
impurity 1
impurity 2
Test animals
- Species:
- guinea pig
- Strain:
- not specified
Test system
- Type of coverage:
- open
- Preparation of test site:
- clipped
- Vehicle:
- other: 10% ethanol
- Controls:
- yes
- Amount / concentration applied:
- concentrations of 30, 10, 3 and 1%
- Duration of treatment / exposure:
- There are 2 parts to this test, a single application and a 21-Day repeated application test.
- Observation period:
- In the single applicaiton test, thre was an observation period of 24 hours
In the repeated dos group, observations were recorded on days 7, 14 and 21 - Number of animals:
- 6-8 animals were used in the single application test.
6 animals per dose (24 total) were used in the repeated application test - Details on study design:
- Under the current OECD guidance, the repeated dose application test can not be used to assess clarification, only to aid irritant levels if a single application is only observed for 24 hours.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: Irritation
- Basis:
- other: 100% concentration
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: Slight Skin Irritation
- Irritation parameter:
- other: Irritation
- Basis:
- other: 30% concentration
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: Slight Skin Irritation
Any other information on results incl. tables
Single application test
Slovent: ethanol
Lowest irritant concentration = 100%
Highest non irritant concentration = 30%
Repeated applications over 21 successive days
Concentration % | Skin irritation after days | ||
7 | 14 | 21 | |
100 | (+) | (+) | + |
30 | - | (+) | (+) |
10 | - | - | - |
3 | - | - | - |
Degree of skin irritation:
– = none
+ = slight
++ = moderate
+++ = strong
Capacity to induce allergic sensitization
After daily applications over three weeks Concentration in % |
Sensitisation rate Number of animals Positive/Total |
|
Day 21 | Day 35 | |
100 | 0/6 | 0/6 |
30 | 0/6 | 0/6 |
10 | 0/6 | 0/6 |
3 | 0/6 | 0/6 |
Results:
STEMONE is a well-tolerated preparation. The highest non-irritant solution after single application is 30%,after repeated applications 10% in ethanol. The 30% solution causes only very slight skin irritation beginning after one week's treatment. No sensitization occurs with STEMONE in the guinea pig under conditions of the OET.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- After a single application, slight irritation was observed at a concentration of 100%.
Although no observations were taken at 48 and 72 hours, the data from the repeated dose study at 7, 14 and 21 days indicates that only slight irritation was observed.
Therefore, after a single application, no additional irritation would be expected which would lead to classification. - Executive summary:
Slight irritation observed after a single application which is insufficient for classification purposes.
This non-classification is based on the additional information after 21 days repeated dosing at 3%, 10%, 30% and 100% where after 7 days dosing at 100%, only slight irritation was observed.
Therefore after a single dose, it is extremely unlikely that oxyoctaline formate would be an irritant after 7 days and therefore would not be classifiable.
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