7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from peer-reviewed journal

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Fragrance raw materials monographs: 4-(p-methoxyphenyl) butan-2-one

Author:

D. L. J. Opdyke

Year:

1974

Bibliographic source:

Food and Cosmetics Toxicology. 12, 929, 1974

Reference 2

Reference Type:

publication

Title:

The FEMA GRAS assessment of aromatic substituted secondary alcohols, ketones, and related esters used as flavor ingredients

Author:

T.B. Adams ,M.M. McGowen , M.C. Williams , S.M. Cohen , V.J. Feron ,J.I. Goodman , L.J. Marnett , I.C. Munro , P.S. Portoghese ,R.L. Smith , W.J. Waddell

Year:

2007

Bibliographic source:

Food and Chemical Toxicology 45 (2007) 171–201

Reference 3

Reference Type:

other: Authoritative database

Title:

Acute oral toxicity study of 4-(4-methoxyphenyl)butan-2-one (104-20-1) in Rat

Author:

U.S. National Library of Medicine

Year:

2017

Bibliographic source:

Chemidplus Database,U.S. National Library of Medicine,2017

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: As mentioned below

Principles of method if other than guideline:

Acute oral toxicity test for substance 4-(4-methoxyphenyl)butan-2-one (104-20-1) was performed in rats.

GLP compliance:

not specified

Test type:

other: No data available

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

4-(4-methoxyphenyl)butan-2-one

Cas Number:

104-20-1

Molecular formula:

C11H14O2

IUPAC Name:

4-(4-methoxyphenyl)butan-2-one

Details on test material:

- Name of test material: 4-(4-Methoxyphenyl)butan-2-one (Anisyl acetone)
- IUPAC name: 4-(4-methoxyphenyl)butan-2-one
- Molecular formula: C11H14O2
- Molecular weight: 178.23 g/mol
- Substance type: Organic

Specific details on test material used for the study:

- Name of test material (as cited in study report):4-(p-methoxyphenyl)butan-2-one
- Molecular formula :C11H14O2
- Molecular weight :178.23 g/mole
- Substance type:Organic
- Physical state:Liquid

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

No data available

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

not specified

Details on oral exposure:

No data available

Doses:

5000 mg/kg bw

No. of animals per sex per dose:

No data available

Control animals:

not specified

Details on study design:

No data available

Statistics:

No data available

Results and discussion

Preliminary study:

No data available

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other: No mortality was observed in treated rats at 5000 mg/kg bw

Mortality:

No mortality was observed in treated rats at 5000 mg/kg bw

Clinical signs:

other: No data available

Gross pathology:

No data available

Other findings:

No data available

Applicant's summary and conclusion

Interpretation of results:

Category 5 based on GHS criteria

Conclusions:

The lethal concentration (LD50) value for acute oral toxicity test was considered to be >5000 mg/kg bw,when rats were treated with 4-(p-methoxyphenyl)butan-2-one (104-20-1) orally.

Executive summary:

Acute oral toxicity study was done in rats using test material 4-(p-methoxyphenyl)butan-2-one (104-20-1) .No mortality was observed at dose 5000 mg/kg bw. Hence,LD50 value was considered to be >5000 mg/kg bw,when rats were treated with 4-(p-methoxyphenyl)butan-2-one (104-20-1)orally.