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EC number: 248-654-8 | CAS number: 27776-01-8
Table 1 Preliminary toxicity results
Treatment (2 administrations at 24-h interval)
Phase I:Pilot study
TS at 250 mg/kg bw/d
TS at 2500 mg/kg bw/d
TS at 5000 mg/kg bw/d
TS at 7500 mg/kg bw/d
TS at 9700 mg/kg bw/d
Phase II:Toxicity assay
TS at 1000 mg/kg bw/d
TS at 1500 mg/kg bw/d
TS at 2000 mg/kg bw/d
Table 2 Micronucleus assay results
(2 administrations at 24-h interval)
Mean number of micronucleated cells per 2000 polychromatic erythrocytes per animal
Mean ratio of normochromaticto polychromatic erythrocytes
TS at 125
TS at 250
TS at 500
Mitomycin C at 8 mg/kg bw/d
The genotoxicity of benzyl toluene (Ugilec 101) was determined in a micronucleus test conducted in vivo with COBS CD-1 (ICR) BR mice using a similar method to the OECD Guideline 474. Solutions were administered by gavage at a constant volume of 10 mL/kg bw. Following preliminary toxicity assay, 500 mg/kg bw/d treatment for 2 days was selected as the maximum tolerated dose, based on high rates of mortality and severe clinical signs observed at higher dosages. Doses of 125, 250, and 500 mg/kg bw/d were administered by oral gavage to groups of 10 mice (5 males and 5 females), in two equal dosages, separated by an interval of 24 hours. Mitomycin C, administered intraperitoneally at a total dose level of 8 mg/kg, served as positive control. Animal were sacrificed 6 hours after the second administration, and bone marrow smears examined for the presence of micronuclei in 2000 polychromatic erythrocytes per mouse and for the ratio NCE/PCE. No significant increased mortality was observed in any treated groups. Signs of toxicity were only observed at the dose of 500 mg/kg bw/d, consisting of hypopnoea, ptosis, ataxia and tremors. The NCE/PCE ratio obtained in all treated animals was similar to that of control animals. The number of micronucleated polychromatic cells in animals given benzyltoluene was similar to that obtained in control animals. Conversely, animals treated with Mitomycin C presented a highly significant increase in the number of micronucleated polychromatic cells. Benzyl toluene was concluded to be negative in the micronucleus test with mice.
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