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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Feb. 2018 - Apr. 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
preliminary test only
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Qualifier:
according to guideline
Guideline:
other: EU Method A.24 (Partition Coefficient - HPLC Method)
GLP compliance:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Remarks on result:
not determinable
Remarks:
not soluble in organic solvent-water mixes

In a preliminary feasibility test, the test item could not be dissolved in any of the organic solvent-water mixes.

The only possibility to solve the test object was the use of pure THF, with the addition of 25 % water the test object precipitated again.

An absorption, higher than the blank, was recorded with UV-detector and without a column, but with a C18 column, or with a RI detector (without and with column), no signal could be assigned to the test item.

Conclusions:
The substance has potential to bioaccumulate in the environment, according to CLP classification criteria for aquatic chronic toxicity (log Kow expected >>4).
Executive summary:

In a non-GLP pre-test, designed to determine suitable HPLC conditions, the test item could NOT be dissolved in any of the organic solvent (methanol, ethanol, acetonitrile, isopropanol, THF) / water mixtures tested, as recommended by OECD 117/EU A24 guideline.

The determination of partition coefficient of the test substance was therefore not possible.

Due to very low water solubility, a high logPow value is considered, as a worst-case.

Description of key information

Experimental determination not feasible.

High log Kow considered (worst-case for bioaccumulation potential).

Key value for chemical safety assessment

Additional information

A fully reliable preliminary test showed that the determination was not experimentally feasible, as the test item is not soluble in organic solvents/water mixes. It is considered as a key study.